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环状RNA_036186通过调控14-3-3ζ介导头颈部鳞状细胞癌进展。

CircRNA_036186 mediates HNSCC progression by regulating 14-3-3ζ.

作者信息

Tang Juan, Yu Donglin, Song Jiaojiao, Li Junfei, Zhang Yijuan, Ma Xiangrui, Wang Wenlong

机构信息

Department of Oral and Maxillofacial Surgery, Binzhou Medical University Hospital, Binzhou, China.

School of Stomatology, Binzhou Medical University, Yantai, China.

出版信息

Front Oncol. 2024 Dec 3;14:1498139. doi: 10.3389/fonc.2024.1498139. eCollection 2024.

DOI:10.3389/fonc.2024.1498139
PMID:39691598
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11649647/
Abstract

INTRODUCTION

Head and neck squamous cell carcinoma (HNSCC) is a prevalent and lethal malignancy, accounting for 95% of head and neck cancers. Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activating protein ZETA (14-3-3ζ) is central to various signalling pathways and is pivotal in tumour progression.

METHODS

Cancerous and corresponding non-cancerous tissue samples were collected from five patients diagnosed with HNSCC. circRNA and mRNA expression profiles were analyzed using high-throughput sequencing techniques. Potential circRNA-microRNA (miRNA)-mRNA interactions were predicted using bioinformatics tools.

RESULTS

The study found that CircRNA_036186 regulates the expression of 14-3-3ζ in HNSCC through miR-193b-5p.

DISCUSSION

These findings suggest that CircRNA_036186 has the potential to be a biomarker and therapeutic target for HNSCC and provide some theoretical basis for further research on the role of circRNA in HNSCC.

摘要

引言

头颈部鳞状细胞癌（HNSCC）是一种常见且致命的恶性肿瘤，占头颈部癌症的95%。酪氨酸3 - 单加氧酶/色氨酸5 - 单加氧酶激活蛋白ZETA（14 - 3 - 3ζ）在各种信号通路中起核心作用，对肿瘤进展至关重要。

方法

从五名被诊断为HNSCC的患者中收集癌组织及相应的非癌组织样本。使用高通量测序技术分析环状RNA（circRNA）和信使核糖核酸（mRNA）表达谱。利用生物信息学工具预测潜在的circRNA - 微小核糖核酸（miRNA）- mRNA相互作用。

结果

研究发现CircRNA_036186通过miR - 193b - 5p调节HNSCC中14 - 3 - 3ζ的表达。

讨论

这些发现表明CircRNA_036186有潜力成为HNSCC的生物标志物和治疗靶点，并为进一步研究circRNA在HNSCC中的作用提供了一些理论依据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5fe/11649647/000b40d555c3/fonc-14-1498139-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5fe/11649647/66b9b655f04a/fonc-14-1498139-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5fe/11649647/17f17f36b5fd/fonc-14-1498139-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5fe/11649647/15d6aeb385ff/fonc-14-1498139-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5fe/11649647/c75290160861/fonc-14-1498139-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5fe/11649647/000b40d555c3/fonc-14-1498139-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5fe/11649647/66b9b655f04a/fonc-14-1498139-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5fe/11649647/17f17f36b5fd/fonc-14-1498139-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5fe/11649647/15d6aeb385ff/fonc-14-1498139-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5fe/11649647/c75290160861/fonc-14-1498139-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5fe/11649647/000b40d555c3/fonc-14-1498139-g005.jpg

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miR-451a Regulates Neuronal Apoptosis by Modulating 14-3-3ζ-JNK Axis upon Flaviviral Infection.miR-451a 通过调节 14-3-3ζ-JNK 轴调控寨卡病毒感染诱导的神经元凋亡。
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