Ren Junjie, Wu Wanxin, Li Jia, Hu Qifang, Zhang Mi, Wang Jing, Li Xiaoming, Li Yanwen, Huang Binbin
Department of Medical Psychology, School of Mental Health and Psychological Science, Anhui Medical University, Hefei, Anhui, China.
Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei, Anhui, China.
Front Psychiatry. 2024 Dec 3;15:1486402. doi: 10.3389/fpsyt.2024.1486402. eCollection 2024.
Exposure to metal could impact women's depression risk. However, the connection and mechanisms between metalloestrogens exposure and depression are still not fully understood. We aim to explore the associations between metalloestrogens and the risk of depression in women across reproductive lifespan.
Using data from NHANES 2011-2018, we employed logistic regression and baknernel machine regression (BKMR) to study links between metalloestrogen exposure and depression in US women. We analyzed how contraceptive use affects this relationship.
The study involved 3,374 adult women, with 345 of them experiencing depression. Our research revealed that certain metalloestrogens like Ba, Ca, Pb, Sb, and Sn were linked to higher depression risk in women, while Hg was associated with lower depression risk in older women. For women aged 18-44, a blend of metalloestrogens showed a significant positive correlation with depression risk, and the likelihood of depression in later years notably rose when the metal mixture concentration reached or exceeded the 60th percentile. Oral contraceptives would have an effect on the impact of metalloestrogen mixture exposure on depression in women during the reproductive stage.
Our study indicates a significant link between metalloestrogen exposure and a higher risk of depression in adult women in the United States. This finding can aid in identifying the connection and enhancing women's mental well-being.
接触金属可能会影响女性患抑郁症的风险。然而，金属雌激素暴露与抑郁症之间的联系和机制仍未完全明确。我们旨在探讨金属雌激素与处于生殖寿命期的女性患抑郁症风险之间的关联。
利用2011 - 2018年美国国家健康与营养检查调查（NHANES）的数据，我们采用逻辑回归和贝叶斯核机器回归（BKMR）来研究美国女性金属雌激素暴露与抑郁症之间的联系。我们分析了使用避孕药如何影响这种关系。
该研究涉及3374名成年女性，其中345人患有抑郁症。我们的研究表明，某些金属雌激素如钡、钙、铅、锑和锡与女性患抑郁症的较高风险相关，而汞与老年女性患抑郁症的较低风险相关。对于18 - 44岁的女性，多种金属雌激素的混合与抑郁症风险呈显著正相关，当金属混合物浓度达到或超过第60百分位数时，晚年患抑郁症的可能性显著增加。口服避孕药会对生殖阶段女性金属雌激素混合物暴露对抑郁症的影响产生作用。
我们的研究表明，在美国成年女性中，金属雌激素暴露与较高的抑郁症风险之间存在显著联系。这一发现有助于明确这种联系并增进女性的心理健康。
