Saint-Martin Florian, Marques Chloé, Ren Xuan, Lequy Emeline, Mancini Francesca Romana, Frénoy Pauline
Université Paris-Saclay, UVSQ, Gustave Roussy, CESP, 94805, Villejuif, Inserm, France.
Environ Health. 2025 Apr 17;24(1):22. doi: 10.1186/s12940-025-01167-6.
Metalloestrogens are ionic metals and metalloids that can activate estrogen receptor, and are suspected to play a role in breast cancer occurrence. This study explored the relationship between dietary exposure profiles to metalloestrogens and estrogen-receptor positive breast cancer (ERP-BC) risk among women in the French E3N cohort.A prospective study was conducted involving 66 722 women who completed a food frequency questionnaire in 1993. Food consumption data were combined with food contamination data obtained from the Second French Total Diet Study, to estimate the dietary intake of 14 metalloestrogens. A principal component analysis was performed to identify the main dietary exposure profiles to metalloestrogens. The retained principal components were included in Cox regression models, used to estimate Hazard Ratios (HR) and their 95% confidence intervals (95% CI) for the associations between the adherence to the identified profiles and ERP-BC risk identified until 2014, adjusted for confounding factors selected using a directed acyclic graph.After an average follow-up of 17.7 years, 3 739 incident cases of ERP-BC were identified. Four principal components were retained, explaining 80.5% of the variance. A statistically significant positive association between the third principal component, mainly characterized by dietary intake of inorganic arsenic and vanadium, and ERP-BC risk was estimated (HR: 1.04, 95% CI: 1.00-1.07, p-value: 0.03). No statistically significant association was found when evaluating the effect of each metalloestrogen individually.The results suggests that even relatively low levels of exposure to inorganic arsenic and vanadium, when combined, could increase the risk of ERP-BC.
金属雌激素是能够激活雌激素受体的离子金属和类金属，被怀疑在乳腺癌的发生中起作用。本研究在法国E3N队列中探讨了女性膳食中金属雌激素暴露情况与雌激素受体阳性乳腺癌（ERP - BC）风险之间的关系。开展了一项前瞻性研究，纳入了1993年完成食物频率问卷的66722名女性。将食物消费数据与法国第二次总膳食研究中获得的食物污染数据相结合，以估算14种金属雌激素的膳食摄入量。进行主成分分析以确定金属雌激素的主要膳食暴露模式。保留的主成分纳入Cox回归模型，用于估计坚持已确定模式与截至2014年所确定的ERP - BC风险之间关联的风险比（HR）及其95%置信区间（95%CI），并针对使用有向无环图选择的混杂因素进行调整。经过平均17.7年的随访，共确定了3739例ERP - BC发病病例。保留了四个主成分，解释了80.5%的变异。估计第三个主要以无机砷和钒的膳食摄入量为特征的主成分与ERP - BC风险之间存在统计学显著的正相关（HR：1.04，95%CI：1.00 - 1.07，p值：0.03）。单独评估每种金属雌激素的作用时未发现统计学显著关联。结果表明，即使是相对较低水平的无机砷和钒暴露，若两者同时存在，也可能增加ERP - BC的风险。
