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左西孟旦对心包切除术后低心排血量综合征的影响。

Effect of Levosimendan on Low Cardiac Output Syndrome After Pericardiectomy.

作者信息

Fang Likui, Zhu Pengfei, Yu Guocan, Lv Wang, Hu Jian

机构信息

Department of Thoracic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, People's Republic of China.

Department of Thoracic Surgery, Hangzhou Red Cross Hospital, Hangzhou, 310003, People's Republic of China.

出版信息

Ther Clin Risk Manag. 2024 Dec 13;20:861-869. doi: 10.2147/TCRM.S496574. eCollection 2024.

DOI:10.2147/TCRM.S496574
PMID:39691940
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11651068/
Abstract

BACKGROUND

Low cardiac output syndrome (LCOS) after pericardiectomy is associated with high morbidity and mortality. This study aimed to assess the effect of levosimendan on postoperative LCOS in the patients with constrictive pericarditis.

METHODS

Patients were retrospectively enrolled, and those receiving the treatment of levosimendan were assigned in the LEVO (+) group, and others were in the LEVO (-) group. Postoperative outcomes including durations of intubation, vasoactive agents using, ICU stay, hospital stay and mortality were compared between the two groups.

RESULTS

A total of 32 patients were eligible for analysis, 19 of whom were in the LEVO (+) group, and 13 of whom were in the LEVO (-) group. The LEVO (+) group was associated with shorter postoperative duration of intubation (P < 0.001), vasopressor using (P = 0.006), ICU stay (P = 0.001) and hospital stay (P = 0.042), and less incidence of acute liver or kidney injury (P = 0.046). There were no significant differences in 30-day mortality and 1-year mortality between the LEVO (+) group and the LEVO (-) group. The prevalence of adverse events in the LEVO (+) group was acceptable.

CONCLUSION

Levosimendan could be administered in the patients with constrictive pericarditis developing LCOS after pericardiectomy to enhanced postoperative recovery.

摘要

背景

心包切除术后低心排血量综合征（LCOS）与高发病率和死亡率相关。本研究旨在评估左西孟旦对缩窄性心包炎患者术后LCOS的影响。

方法

对患者进行回顾性纳入，接受左西孟旦治疗的患者被分配到LEVO（+）组，其他患者则为LEVO（-）组。比较两组患者术后包括插管时间、血管活性药物使用时间、重症监护病房（ICU）住院时间、住院时间和死亡率等结果。

结果

共有32例患者符合分析条件，其中19例在LEVO（+）组，13例在LEVO（-）组。LEVO（+）组术后插管时间（P<0.001）、血管升压药使用时间（P = 0.006）、ICU住院时间（P = 0.001）和住院时间（P = 0.042）均较短，急性肝或肾损伤发生率较低（P = 0.046）。LEVO（+）组与LEVO（-）组在30天死亡率和1年死亡率方面无显著差异。LEVO（+）组不良事件的发生率可以接受。

结论

对于心包切除术后发生LCOS的缩窄性心包炎患者，可给予左西孟旦以促进术后恢复。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/491d/11651068/45053411dbcf/TCRM-20-861-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/491d/11651068/2d7f5d3845cd/TCRM-20-861-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/491d/11651068/45053411dbcf/TCRM-20-861-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/491d/11651068/2d7f5d3845cd/TCRM-20-861-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/491d/11651068/45053411dbcf/TCRM-20-861-g0002.jpg

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Levosimendan and Low Cardiac Output After Cardiac Surgery: Analysis of Trial Data.左西孟旦与心脏手术后低心排血量：试验数据分析
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