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在乳腺癌细胞系中敲低HGH1可抑制肿瘤细胞的活力、侵袭和迁移。

Knockdown of HGH1 in breast cancer cell lines can inhibit the viability, invasion and migration of tumor cells.

作者信息

Wang Zeyu, Liu Taiyuan, He Kang, Wang Longyun, Ma Xiaoxuan, Yang Zhaoyun, Zhang Yingchao, Zhao Lijing

机构信息

Department of Rehabilitation, School of Nursing, Jilin University, Changchun, China.

Department of Breast Surgery, Second Hospital of Jilin University, Changchun, China.

出版信息

Cell Adh Migr. 2025 Dec;19(1):1-14. doi: 10.1080/19336918.2024.2442349. Epub 2024 Dec 18.

DOI:10.1080/19336918.2024.2442349
PMID:39691959
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11657051/
Abstract

BACKGROUND

Research on the function of HGH1 in breast cancer remains lacking.

METHODS

TCGAand GEO (GSE45827) datasets investigated discrepancies in HGH1 expression in BC. An aggregate of 106 clinical samples were gathered through immunohistochemistry, KM curves were drawn for prognostic analysis, and the function of HGH1 of BC was predicted. Finally, the effects of HGH1 knockdown on MDA-MB-231 and MCF-7 BC cells were verified via CCK8, invasion, wound healing and colony formation assays.

RESULTS

HGH1 is highly expressed in BC and is linked to unfavorable prognosis. HGH1 overexpression is connected to keratinization and the cell cycle and is closely related to ER and PR expression and tumor stage in BC patients. Knocking down HGH1 in BC cells inhibited the viability, invasion and migration.

CONCLUSION

Knockdown of HGH1 in breast cancer cell lines can inhibit the viability, invasion and migration of tumor cells.

摘要

背景

关于HGH1在乳腺癌中功能的研究仍然缺乏。

方法

利用TCGA和GEO（GSE45827）数据集研究乳腺癌中HGH1表达的差异。通过免疫组织化学收集了106个临床样本，绘制KM曲线进行预后分析，并预测乳腺癌中HGH1的功能。最后，通过CCK8、侵袭、伤口愈合和集落形成实验验证了HGH1基因敲低对MDA-MB-231和MCF-7乳腺癌细胞的影响。

结果

HGH1在乳腺癌中高表达，并与不良预后相关。HGH1的过表达与角质化和细胞周期有关，并且与乳腺癌患者的雌激素受体（ER）、孕激素受体（PR）表达以及肿瘤分期密切相关。在乳腺癌细胞中敲低HGH1可抑制其活力、侵袭和迁移能力。

结论

在乳腺癌细胞系中敲低HGH1可抑制肿瘤细胞的活力、侵袭和迁移能力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc96/11657051/44dc92341059/KCAM_A_2442349_F0007_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc96/11657051/fc8ce1b3afaa/KCAM_A_2442349_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc96/11657051/acbd38abfad2/KCAM_A_2442349_F0002_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc96/11657051/8e56b75b4baf/KCAM_A_2442349_F0003_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc96/11657051/fd596d437f15/KCAM_A_2442349_F0004_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc96/11657051/a508a784f79b/KCAM_A_2442349_F0005_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc96/11657051/81b8cc16c05a/KCAM_A_2442349_F0006_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc96/11657051/44dc92341059/KCAM_A_2442349_F0007_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc96/11657051/fc8ce1b3afaa/KCAM_A_2442349_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc96/11657051/acbd38abfad2/KCAM_A_2442349_F0002_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc96/11657051/8e56b75b4baf/KCAM_A_2442349_F0003_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc96/11657051/fd596d437f15/KCAM_A_2442349_F0004_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc96/11657051/a508a784f79b/KCAM_A_2442349_F0005_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc96/11657051/81b8cc16c05a/KCAM_A_2442349_F0006_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc96/11657051/44dc92341059/KCAM_A_2442349_F0007_OC.jpg

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