肝硬化患者筛查性内镜检查中诊断出的无症状消化性溃疡疾病的流行病学

Epidemiology of asymptomatic peptic ulcer disease diagnosed during screening endoscopy in patients with cirrhosis.

作者信息

Lema Girma Deshimo, Gebeyaw Enguday Demeke

机构信息

School of Medicine, Asrat Woldeyes Health Science Campus, Debre Berhan University, Debre Berhan, Ethiopia.

School of Public Health, Asrat Woldeyes Health Science Campus, Debre Berhan University, Debre Berhan, Ethiopia.

出版信息

J Int Med Res. 2024 Dec;52(12):3000605241305258. doi: 10.1177/03000605241305258.

DOI:10.1177/03000605241305258

PMID:39692022

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11653440/

Abstract

OBJECTIVE

Asymptomatic peptic ulcer disease (PUD) is frequently overlooked in patients with cirrhosis, who are at increased risk for gastrointestinal complications that can lead to increased morbidity and mortality. We aimed to determine the prevalence and associated factors of asymptomatic PUD identified during screening endoscopy in patients with cirrhosis.

METHODS

We conducted a retrospective cross-sectional study among patients with cirrhosis at St. Paul's Hospital Millennium Medical College in Ethiopia. Data were collected using a structured questionnaire from patients' medical charts. A logistic regression model was used to identify predictors of peptic ulcer.

RESULTS

This study included 296 patients, revealing that 19.6% had PUD (95% confidence interval: 13.5-26.4). Significant associations were found between peptic ulcer and infection, moderate and heavy alcohol consumption, and Child-Pugh class C cirrhosis.

CONCLUSION

We found that patients with liver cirrhosis are more likely to have asymptomatic peptic ulcers. Asymptomatic PUD was linked to infection, greater alcohol consumption, and Child-Pugh class C liver disease, highlighting the need for targeted prevention and management strategies to reduce morbidity in patients with cirrhosis, such as eradication therapy for and counseling on alcohol use.

摘要