Sun Yan, Sun Mingwei, Zeng Xia, Xiang Je Liojuan, Su Guo Zhannguo
Department of Emergency Medicine, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, 610072, China.
Chongqing Sport Education College, Chongqing, 404147, China.
Acta Diabetol. 2025 Jan;62(1):11-24. doi: 10.1007/s00592-024-02413-y. Epub 2024 Dec 18.
Type 2 diabetes mellitus (T2DM) is prevalent worldwide, often manageable through lifestyle changes like physical activity. This meta-analysis aimed to determine the effect of resistance training (RT) on cardiovascular risk factors in adults with T2DM.
Four databases were searched up to March 2024. The mean difference (MD) was calculated by a random effect model with 95% confidence interval (CI).
Forty-eight articles were included in the review. There was a significant pooled effect size for the meta-analysis comparing RT vs. control on hemoglobin A1C (MD = -0.49, 95% CI: -0.66, -0.33; P < 0.00001), fasting blood sugar (MD = -11.58, 95% CI: -18.61, -4.55; P = 0.001), insulin (ES = -1.65, 95% CI: -2.87, -0.42; P = 0.008), HOMA-IR (MD = -1.20, 95% CI: -1.85, -0.55; P = 0.0003), triglyceride (MD = -18.14, 95% CI: -30.32, -5.96; P = 0.004), and high-density lipoprotein (MD = 2.71, 95% CI: 0.78, 4.64; P = 0.006). Moreover, RT was effective for reducing body weight (MD = -0.81, 95% CI: -1.50, -0.13; P = 0.02), fat percentage (MD = -0.92, 95% CI: -1.62, -0.22; P = 0.010), and waist circumference (MD = -2.14, 95% CI: -3.00, -1.28; P < 0.00001).
RT effectively improves cardiovascular risk factors in T2DM adults, suggesting potential as treatment or prevention. Future studies can consider investigating the optimal RT regimen to achieve effective T2DM management in adults.
2型糖尿病（T2DM）在全球范围内普遍存在，通常可通过体育活动等生活方式改变来控制。本荟萃分析旨在确定抗阻训练（RT）对成年T2DM患者心血管危险因素的影响。
检索了截至2024年3月的四个数据库。采用随机效应模型计算平均差（MD）及95%置信区间（CI）。
该综述纳入了48篇文章。在比较RT与对照组对糖化血红蛋白（MD = -0.49，95% CI：-0.66，-0.33；P < 0.00001）、空腹血糖（MD = -11.58，95% CI：-18.61，-4.55；P = 0.001）、胰岛素（ES = -1.65，95% CI：-2.87，-0.42；P = 0.008）、胰岛素抵抗指数（HOMA-IR，MD = -1.20，95% CI：-1.85，-0.55；P = 0.0003）、甘油三酯（MD = -18.14，95% CI：-30.32，-5.96；P = 0.004）和高密度脂蛋白（MD = 2.71，95% CI：0.78，4.64；P = 0.006）方面，荟萃分析有显著的合并效应量。此外，RT在减轻体重（MD = -0.81，95% CI：-1.50，-0.13；P = 0.02）、体脂百分比（MD = -0.92，95% CI：-1.62，-0.22；P = 0.010）和腰围（MD = -2.14，95% CI：-3.00，-1.28；P < 0.00001）方面有效。
RT可有效改善成年T2DM患者的心血管危险因素，提示其在治疗或预防方面具有潜力。未来研究可考虑探究最佳RT方案，以实现对成年T2DM的有效管理。
