Yang Chang-Hang, Li Cai-Wei, Sie Yi-Yan, Chen Liang-Chieh, Yuan Yu-Hsiang, Hou Wen-Chi
Graduate Institute of Pharmacognosy, Taipei Medical University, Taipei, 110, Taiwan.
Clinical Drug Development of Herbal Medicine, College of Pharmacy, Taipei Medical University, Taipei, 110, Taiwan.
Bot Stud. 2024 Dec 18;65(1):38. doi: 10.1186/s40529-024-00443-x.
Hispolon, one of bioactive phenolic compounds from a medicinal mushroom of sang-huang (Phellinus linteus) has been reported to exhibit anticancer and anti-inflammatory activities. The Alzheimer's disease (AD) is ranked one of the top ten leading causes of death worldwide. Little is known about the effects of hispolon on delaying AD progression.
The hispolon (No.1) and its six structural analogs (No.2 to No.7) were assayed by antioxidant, anti-acetylcholinesterase activities and anti-amyloid-β-peptide aggregations. The No.1, No.6, and No.7 were selected for further molecular docking with acetylcholinesterase and core fragments of amyloid-β-peptide, and also showed capacities to recover cell viabilities in methylglyoxal-treated SH-SY5Y cells and also to enhance neurite outgrowths in PC12 cells. The daily pre-treatments of No.1, No.6, and No.7 for 10-days (40 mg/kg/day) showed to improve learning dysfunctions in scopolamine-induced ICR mice by passive avoidance tests.
The hispolon in the fungus sang-huang might be beneficial to develop functional foods or as lead compounds for treating degenerative disorders.
桑黄（裂蹄木层孔菌）中的生物活性酚类化合物之一桑黄酚已被报道具有抗癌和抗炎活性。阿尔茨海默病（AD）是全球十大主要死因之一。关于桑黄酚对延缓AD进展的影响知之甚少。
对桑黄酚（1号）及其六种结构类似物（2号至7号）进行了抗氧化、抗乙酰胆碱酯酶活性和抗淀粉样β肽聚集的测定。选择1号、6号和7号与乙酰胆碱酯酶和淀粉样β肽的核心片段进行进一步的分子对接，它们还显示出能够恢复甲基乙二醛处理的SH-SY5Y细胞的细胞活力，并增强PC12细胞的神经突生长。1号、6号和7号连续10天（40毫克/千克/天）每日预处理，通过被动回避试验显示可改善东莨菪碱诱导的ICR小鼠的学习功能障碍。
桑黄中的桑黄酚可能有利于开发功能性食品或作为治疗退行性疾病的先导化合物。
