Marquez-Romero Juan Manuel, Sánchez-Ramírez Karen Itzel
Department of Neurology, Hospital General de Zona #2, IMSS, OOAD Aguascalientes, Av. los Conos No. 102, 20190, Aguascalientes, AGS, Mexico.
Facultad de Medicina, Universidad Autónoma de Sinaloa, C. Sauces, s/n, 80019, Culiacán, SIN, Mexico.
Clin Auton Res. 2025 Feb;35(1):31-43. doi: 10.1007/s10286-024-01085-6. Epub 2024 Dec 18.
The parasympathetic effects of the sphenopalatine ganglion (SPG) on the cerebral vasculature provide a compelling rationale for its therapeutic application in cerebrovascular ischemia. In recent years, attempts have been made to stimulate the SPG to achieve beneficial effects on cerebral circulation.
This review synthesizes the available publications on SPG stimulation. It critically evaluates the evidence from preclinical studies and clinical trials to assess its potential as a treatment for acute cerebrovascular disorders and outlines aspects that still require more study.
The medical literature provides consistent evidence of the significant effects of stimulating the SPG on cerebrovascular circulation. In addition, considerable evidence supports the therapeutic role of SPG stimulation in patients with cerebral ischemia.
Given the current understanding, future research could explore the potential of SPG stimulation as a non-reperfusion intervention to improve long-term outcomes for individuals with ischemic cerebrovascular conditions.
蝶腭神经节（SPG）对脑血管系统的副交感神经作用为其在脑血管缺血治疗中的应用提供了令人信服的理论依据。近年来，人们尝试刺激SPG以对脑循环产生有益影响。
本综述综合了关于SPG刺激的现有出版物。它严格评估了来自临床前研究和临床试验的证据，以评估其作为急性脑血管疾病治疗方法的潜力，并概述了仍需更多研究的方面。
医学文献提供了一致的证据，证明刺激SPG对脑血管循环有显著影响。此外，大量证据支持SPG刺激在脑缺血患者中的治疗作用。
基于目前的认识，未来的研究可以探索SPG刺激作为一种非再灌注干预措施的潜力，以改善缺血性脑血管疾病患者的长期预后。
