恶性卵巢性索间质肿瘤的治疗现状
Current status of treatment for malignant ovarian sex cord-stromal tumors.
作者信息
Chunli Fang, Hailin Chen, Yingying Zhou, Huajing Xiao, Boqun Xu
机构信息
Department of Gynecology, The Second Affiliated Hospital of Nanjing Medical University, Nanjing City, Jiangsu Province, China.
出版信息
Discov Oncol. 2024 Dec 18;15(1):799. doi: 10.1007/s12672-024-01687-6.
Abstract
Malignant ovarian sex cord-stromal tumors belong to a specific type of ovarian epithelial carcinoma, and their prognosis is related to the kind of pathology. Unlike epithelial ovarian cancer, most malignant ovarian sex cord-stromal tumors are low-grade malignant and have a good prognosis. Still, they have a tendency to recur in the long term, and the mortality rate of patients after recurrence is high. Surgery is the preferred treatment for malignant ovarian sex cord-stromal tumors with chemotherapy, and other comprehensive treatments. Recurrent and metastatic malignant ovarian sex cord-stromal tumors usually require systemic adjuvant chemotherapy, and hormonal or targeted therapy may be attempted on an individualized basis in cases where chemotherapy fails.
摘要
恶性卵巢性索间质肿瘤属于卵巢上皮癌的一种特殊类型，其预后与病理类型有关。与上皮性卵巢癌不同，大多数恶性卵巢性索间质肿瘤为低级别恶性，预后良好。然而，它们有长期复发的倾向，复发后患者的死亡率很高。手术是恶性卵巢性索间质肿瘤的首选治疗方法，辅以化疗及其他综合治疗。复发性和转移性恶性卵巢性索间质肿瘤通常需要全身辅助化疗，化疗失败的情况下可根据个体情况尝试激素或靶向治疗。
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