Posner P, Prestwich K N, Buss D D
Pediatr Res. 1985 Jan;19(1):64-6. doi: 10.1203/00006450-198501000-00017.
Newborn rabbits were raised in either hypoxic or normoxic environments for 3 months. Data from electrophysiological studies carried out on isolated sinoatrial and ventricular preparations from the two groups show that the hypoxic group had changes in cellular transmembrane electrical activity that could be the basis for disorders of rate and conduction in vivo. This model will be useful to study the etiology and therapy of some arrhythmias seen in cyanotic congenital hypoxemic heart disease.
将新生兔置于缺氧或常氧环境中饲养3个月。对两组分离的窦房结和心室标本进行电生理研究的数据表明，缺氧组细胞跨膜电活动发生了变化，这可能是体内心率和传导紊乱的基础。该模型将有助于研究紫绀型先天性低氧性心脏病中所见某些心律失常的病因和治疗方法。
