Benagiano Giuseppe, Genazzani Andrea R, Grandi Giovanni, Guo Sun-Wei, Habiba Marwan
Faculty of Medicine and Dentistry, 'Sapienza', University of Rome, Rome, Italy.
Geneva Foundation for Medical Education and Research, Geneva, Switzerland.
PLoS Comput Biol. 2024 Dec 18;20(12):e1012398. doi: 10.1371/journal.pcbi.1012398. eCollection 2024 Dec.
The optimal contraception dosing strategy proposed by Gavina et al. recently is a commendable attempt to model a complex physiological process with potenial to apply to real-life data. However, there is a need to take into account the real challenges that arise when moving from the theory to its practical application, and it is important that lessons learnt from clinical studies be taken into consideration in any theoretical modelling. In this manuscript, we spell out these lessons and elaborate practical challenges facing their model.
加维纳等人最近提出的最佳避孕剂量策略，是对一个复杂生理过程进行建模的值得称赞的尝试，该过程有可能应用于实际生活数据。然而，在从理论转向实际应用时，需要考虑到出现的实际挑战，并且在任何理论建模中都应考虑从临床研究中吸取的经验教训。在本手稿中，我们阐述了这些经验教训，并详细说明了他们的模型所面临的实际挑战。
