WHAT IS THE REIMBURSEMENT RECOMMENDATION FOR CABTREO?: It is recommended that Cabtreo be reimbursed by public drug plans for the topical treatment of acne vulgaris in patients 12 years of age and older if certain conditions are met. WHICH PATIENTS ARE ELIGIBLE FOR COVERAGE? Cabtreo should only be covered to treat patients 12 years of age and older with acne vulgaris. WHAT ARE THE CONDITIONS FOR REIMBURSEMENT? Cabtreo should only be reimbursed if the price of Cabtreo is negotiated so that it does not exceed the drug program cost of treatment with topical therapy for acne vulgaris reimbursed by participating plans. WHY DID CANADA’S DRUG AGENCY MAKE THIS RECOMMENDATION? • Evidence from 2 clinical trials showed that treatment with Cabtreo increased the rate of treatment success (measured using an acne severity scale) and reduced the number of inflammatory and noninflammatory lesions after 12 weeks of treatment compared with its vehicle gel (without an active ingredient). • The treatment effect of Cabtreo on acne, compared with topical treatments that are a combination of 2 active ingredients, was uncertain based on evidence from 1 indirect treatment comparison (ITC). • Cabtreo may meet some of the unmet needs identified by patients, including access to effective and safe treatment options. • Based on our assessment of the health economic evidence, Cabtreo does not represent good value to the health care system at the public list price. The committee determined that there is not enough evidence to justify a greater cost for Cabtreo than the topical therapies currently reimbursed by participating plans. • Based on public list prices, Cabtreo is estimated to cost the public drug plans approximately $2,000,000 over the next 3 years.
WHAT IS ACNE VULGARIS? Acne vulgaris (also called acne) is a skin condition characterized by noninflammatory lesions (open or closed comedones) and inflammatory lesions (papules, pustules, and nodules) that usually develop on the face, neck, upper back, and chest. Acne affects 5,600,000 individuals living in Canada, nearly 20% of the population. UNMET NEEDS IN ACNE VULGARIS: Patients identified a need for access to effective and safe treatment options. The clinical expert identified a need for treatment formulations that are more convenient by reducing the need for several products. HOW MUCH DOES CABTREO COST? Treatment with Cabtreo is expected to cost approximately $1,616 per patient per year.
