Palshof Frederik K, Mørch Lina S, Jensen Maj-Britt R, Storm Hans H, Kroman Niels, Tvedskov Tove H F
The Danish Cancer Society, Danish Cancer Institute, Strandboulevarden 49, 2100 Copenhagen Ø, Denmark; Department of Breast Surgery, Gentofte Hospital, Gentofte Hospitalsvej 1, 2900 Hellerup, Denmark.
The Danish Cancer Society, Danish Cancer Institute, Strandboulevarden 49, 2100 Copenhagen Ø, Denmark.
Breast. 2025 Feb;79:103860. doi: 10.1016/j.breast.2024.103860. Epub 2024 Dec 15.
Increasing life expectancy increases breast cancer (BC) rates in elderly, where better health allows for improved tolerance of treatments. We assessed trends in BC incidence of tumor subtypes for women with focus on the elderly.
Changes in BC incidence in women by age from 2012 to 2021 were assessed using data from the Nordic countries. We calculated the incidence of BC subtypes by age group using data from the Danish Breast Cancer Group (DBCG) database. We used generalized linear models assuming a Poisson distribution.
In the Nordic countries, 205 305 women were diagnosed with BC between 2012 and 2021. In Denmark, 50 858 BC patients were diagnosed between 2012 and 2022, identified with tumor characteristics. Incidence of BC among women aged 80+ increased significantly across the Nordic Countries, with 1.24 % per year (95 % CI: 0.07 %: 2.41 %). In Denmark, in the 80+ group, the ER+/HER2- subtype had the highest increase, with 1.98 % per year (95 % CI: 1.10 %: 2.87 %).
Across the Nordic countries, incidence of BC in women aged 80+ increased. In Denmark, rising incidence of BC is driven by the ER+/HER2- subtype in the 80+ group, which has the best prognosis and gentle treatments. More elderly BC patients will require treatment and follow-up in the future.
预期寿命的增加导致老年女性乳腺癌（BC）发病率上升，因为更好的健康状况使她们对治疗的耐受性提高。我们评估了以老年女性为重点的肿瘤亚型的BC发病率趋势。
利用北欧国家的数据评估了2012年至2021年按年龄划分的女性BC发病率变化。我们使用丹麦乳腺癌组（DBCG）数据库的数据计算了各年龄组的BC亚型发病率。我们使用了假定为泊松分布的广义线性模型。
在北欧国家，2012年至2021年期间有205305名女性被诊断为BC。在丹麦，2012年至2022年期间有50858名BC患者被诊断，并确定了肿瘤特征。北欧国家80岁及以上女性的BC发病率显著上升，每年上升1.24%（95%CI：0.07%：2.41%）。在丹麦，80岁及以上年龄组中，ER+/HER2-亚型的发病率上升最高，每年上升1.98%（95%CI：1.10%：2.87%）。
在北欧国家，80岁及以上女性的BC发病率上升。在丹麦，80岁及以上年龄组中BC发病率的上升是由ER+/HER2-亚型推动的，该亚型预后最佳且治疗温和。未来将有更多老年BC患者需要治疗和随访。
