Taylor J M
Radiat Res. 1985 Jan;101(1):156-61.
H. D. Thames, Jr. and H. R. Withers [Br. J. Radiol. 53, 1071-1077 (1980)] propose a test of an equal effect per fraction in microcolony assays after fractionated radiation, in which the total effect is measured by counting microcolonies derived from surviving cells in a tissue. The factors considered to influence the cytocidal effect per fraction are incomplete repair, repopulation, and synchrony. The statistics used in the method are criticized and conditions are given under which the test should not be used. An alternative method of testing for an equal effect per fraction is proposed. The pros and cons of each test are discussed and compared using some mouse jejunal crypt cell survival data.
小H. D. 泰晤士和H. R. 威瑟斯[《英国放射学杂志》53, 1071 - 1077 (1980)]提出了一种在分次放疗后的微集落试验中检验每次分割剂量等效效应的方法，其中总效应通过计数组织中存活细胞衍生的微集落来测量。被认为影响每次分割剂量细胞杀伤效应的因素包括不完全修复、再增殖和同步化。该方法中使用的统计学方法受到批评，并给出了不应使用该检验的条件。提出了另一种检验每次分割剂量等效效应的方法。使用一些小鼠空肠隐窝细胞存活数据讨论并比较了每种检验方法的优缺点。
