Dambly Julia Margaret, Hunter Emily R, Giakas Alec M, Glowacki Joseph B
Infectious Diseases, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, USA
Infectious Diseases, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, USA.
BMJ Case Rep. 2024 Dec 18;17(12):e262362. doi: 10.1136/bcr-2024-262362.
Necrotising fasciitis (NF) is a severe, rapidly progressing infection of the muscular fascia and subcutaneous tissue. Monomicrobial NF from hypermucoviscous (hvKP-NF) is rare but highly virulent, most common in East Asia. This report reviews a unique case of hvKP-NF in a US male in his 40s with undiagnosed diabetes mellitus, presenting with severe sepsis, neck swelling and calf pain. Imaging revealed pyomyositis in the sternocleidomastoid, and debridement cultures confirmed hvKP. Despite unremarkable examination findings, persistent pain led to a diagnosis of necrotising fasciitis after initial imaging misinterpretations. The patient was treated with multiple surgical debridements and tailored antibiotics. This case underscores the importance of maintaining a high index of suspicion for necrotising fasciitis despite atypical risk factors and symptomatology, awareness of hvKP in the Western Hemisphere, prompt consideration of advanced imaging modalities when initial evaluations are inconclusive and the critical role of multidisciplinary care in managing severe infections.
坏死性筋膜炎(NF)是一种严重的、进展迅速的肌肉筋膜和皮下组织感染。由高黏液性肺炎克雷伯菌引起的单微生物坏死性筋膜炎(hvKP-NF)较为罕见,但毒力很强,在东亚最为常见。本报告回顾了一例独特的hvKP-NF病例,患者为一名40多岁的美国男性,患有未确诊的糖尿病,表现为严重脓毒症、颈部肿胀和小腿疼痛。影像学检查显示胸锁乳突肌有脓性肌炎,清创培养证实为hvKP。尽管检查结果无异常,但持续疼痛导致在最初影像学误诊后诊断为坏死性筋膜炎。患者接受了多次手术清创和针对性抗生素治疗。该病例强调了尽管存在非典型危险因素和症状,仍需对坏死性筋膜炎保持高度怀疑指数的重要性,意识到西半球存在hvKP,在初始评估无定论时及时考虑采用先进的影像学检查方法,以及多学科护理在管理严重感染中的关键作用。