Zhang Qi, Tang Jiahui, Liu Liyan, Liu Zhe, Xue Jingfei, Ge Jian, Zhuo Yehong, Li Yiqing
State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Sun Yat-sen University, Guangzhou 510060, China.
State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Sun Yat-sen University, Guangzhou 510060, China; Department of Ophthalmology, The Key Laboratory of Advanced Interdisciplinary Studies Center, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China.
Trends Pharmacol Sci. 2025 Jan;46(1):45-61. doi: 10.1016/j.tips.2024.11.008. Epub 2024 Dec 17.
The optic nerve, comprising axons from retinal ganglion cells (RGCs), is a component of the central nervous system (CNS) that generally exhibits a limited regeneration capacity following injury in mature mammals, resulting in permanent vision loss. Here, we summarize recent advances in interventions targeting cell-intrinsic and cell-extrinsic mechanisms to enhance RGC axon regeneration. Additionally, we summarize strategies for guiding the reconnection of regenerating axons with brain visual targets, aiming to restore partial visual function. Given the advent of high-throughput screening techniques and multiomics analyses, we discuss how these emerging methodologies deepen our understanding of regenerative mechanisms and expedite the development of innovative therapeutic approaches. Lastly, we explore the translational potential of these strategies in achieving clinically meaningful vision recovery.
视神经由视网膜神经节细胞（RGCs）的轴突组成，是中枢神经系统（CNS）的一个组成部分，在成熟哺乳动物中，视神经在损伤后通常表现出有限的再生能力，导致永久性视力丧失。在此，我们总结了针对细胞内在和细胞外在机制以增强RGC轴突再生的干预措施的最新进展。此外，我们总结了引导再生轴突与脑视觉靶点重新连接的策略，旨在恢复部分视觉功能。鉴于高通量筛选技术和多组学分析的出现，我们讨论了这些新兴方法如何加深我们对再生机制的理解并加速创新治疗方法的开发。最后，我们探讨了这些策略在实现具有临床意义的视力恢复方面的转化潜力。
