Recinella Lucia, Libero Maria Loreta, Brunetti Luigi, Acquaviva Alessandra, Chiavaroli Annalisa, Orlando Giustino, Granata Riccarda, Salvatori Roberto, Leone Sheila
Department of Pharmacy, G. d'Annunzio University of Chieti-Pescara, Chieti, Italy.
Department of Medical Sciences, University of Turin, Turin, Italy.
Rev Endocr Metab Disord. 2024 Dec 18. doi: 10.1007/s11154-024-09936-3.
This paper provides a critical overview on GHRH and its deficiency, discussing its multiple roles in both central and peripheral tissues. Genetically engineered mice have been instrumental in elucidating the multifaceted roles of GHRH and GH, each offering unique insights into the physiological and pathological roles of these hormones, although in many of these models dissecting the direct effect of GHRH from the effect of GH is not possible. Key findings highlight the effects of GHRH deficiency on emotional behavior, including anxiety and depression, its impact on memory and learning capabilities, as well as on adipose tissue, immune system, inflammation and pain.
本文对生长激素释放激素（GHRH）及其缺乏症进行了批判性综述，讨论了其在中枢和外周组织中的多种作用。基因工程小鼠有助于阐明GHRH和生长激素（GH）的多方面作用，尽管在许多这些模型中，无法区分GHRH的直接作用和GH的作用，但每种小鼠都为这些激素的生理和病理作用提供了独特的见解。主要研究结果突出了GHRH缺乏对情绪行为的影响，包括焦虑和抑郁，其对记忆和学习能力的影响，以及对脂肪组织、免疫系统、炎症和疼痛的影响。
