Gössi U, Bucher U, Brun del Re G, Miloni E, Hess T
Schweiz Med Wochenschr. 1985 Jan 12;115(2):34-40.
A 50-year-old severely immunodeficient woman with malignant non-Hodgkin lymphoma died from graft-versus-host disease due to transfusion of a single unit of packed red cells. Three days after this transfusion a maculo-papular rash appeared, followed by generalized erythroderma refractory to therapy and eventually progressing into generalized ulcero-squamous dermatitis. This case, and a review of other similar cases published elsewhere, prompt the authors to recommend prophylactic irradiation of blood products prior to their administration to patients with cellular immunodeficiency, particularly in cases of acute leukaemia or malignant lymphoma where patients receive intensive radio- and/or chemotherapy regimens. To appreciate the degree of cellular immunodeficiency in such risk patients, simple criteria should be developed to assess the efficiency of the cellular immune system.
一名50岁患有恶性非霍奇金淋巴瘤的严重免疫缺陷女性因输注单单位浓缩红细胞而死于移植物抗宿主病。输血三天后出现斑丘疹，随后发展为对治疗无效的全身性红皮病，最终进展为全身性溃疡性鳞状皮炎。该病例以及对其他地方发表的其他类似病例的回顾促使作者建议，在向细胞免疫缺陷患者输注血液制品之前对其进行预防性照射，特别是在急性白血病或恶性淋巴瘤患者接受强化放疗和/或化疗方案的情况下。为了评估此类高危患者的细胞免疫缺陷程度，应制定简单的标准来评估细胞免疫系统的效能。
