Duan Shuyin, Tu Zhanwen, Duan Lijuan, Tu Runqi
School of Public Health, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, China.
Suzhou Medical College of Soochow University, 199 Renai Road, Suzhou, Jiangsu, China.
BMC Gastroenterol. 2024 Dec 18;24(1):463. doi: 10.1186/s12876-024-03557-5.
Several studies have demonstrated that systemic immune inflammation index (SII) has a positive relationship with hepatic steatosis. However, it is lack of system evidence for the correlation between SII and hepatic fibrosis. The objective of this study was to evaluate the relationships between SII and hepatic steatosis or hepatic fibrosis.
A cross-sectional analysis was performed from the National Health and Nutrition Examination Survey (NHANES). Fibrosis-4 index (FIB-4), NAFLD fibrosis score (NFS) and hepamet fibrosis score (HFS) were the indicators for hepatic fibrosis; fatty liver index (FLI), NAFLD liver fat score (LFS) and Framingham steatosis index (FSI) were the indicators for hepatic steatosis. Pearson's test, generalized linear model (GLM) and restricted cubic splines (RCS) were used to analyze associations of SII with hepatic fibrosis and hepatic steatosis.
A total of 21,833 participants were enrolled in the study. Pearson's test and GLM revealed that there were negative relationships between SII and hepatic fibrosis (FIB-4, NFS and HFS), while positive relationships between SII and hepatic steatosis (FLI, LFS and FSI). The corresponding β (95%CI) of SII and hepatic fibrosis were - 0.35(-0.46, -0.24), -0.67(-0.71, -0.63) and - 0.10(-0.12, -0.09), respectively. The corresponding β (95%CI) of SII and hepatic steatosis were 6.12(4.75, 7.50), 0.22(0.12, 0.31) and 0.27(0.20, 0.34), respectively. Statistically significant non-linear association were found in SII with hepatic fibrosis and hepatic steatosis in RCS model (all P < 0.001).
There was a negative significant association between SII and hepatic fibrosis, while a positive significant association between SII and hepatic steatosis.
多项研究表明，全身免疫炎症指数（SII）与肝脂肪变性呈正相关。然而，SII与肝纤维化之间的相关性缺乏系统证据。本研究的目的是评估SII与肝脂肪变性或肝纤维化之间的关系。
对美国国家健康与营养检查调查（NHANES）进行横断面分析。纤维化-4指数（FIB-4）、非酒精性脂肪性肝病纤维化评分（NFS）和肝纤维化评分（HFS）是肝纤维化的指标；脂肪肝指数（FLI）、非酒精性脂肪性肝病肝脏脂肪评分（LFS）和弗雷明汉姆脂肪变性指数（FSI）是肝脂肪变性的指标。采用Pearson检验、广义线性模型（GLM）和受限立方样条（RCS）分析SII与肝纤维化和肝脂肪变性的相关性。
本研究共纳入21,833名参与者。Pearson检验和GLM显示，SII与肝纤维化（FIB-4、NFS和HFS）呈负相关，而SII与肝脂肪变性（FLI、LFS和FSI）呈正相关。SII与肝纤维化的相应β（95%CI）分别为-0.35（-0.46，-0.24）、-0.67（-0.71，-0.63）和-0.10（-0.12，-0.09）。SII与肝脂肪变性的相应β（95%CI）分别为6.12（4.75，7.50）、0.22（0.12，0.31）和0.27（0.20，0.34）。在RCS模型中，SII与肝纤维化和肝脂肪变性存在统计学显著的非线性关联（所有P<0.001）。
SII与肝纤维化呈显著负相关，而SII与肝脂肪变性呈显著正相关。
