Axelrod Margaret L, Liu Xiuli, Navale Pooja
Department of Pathology, Washington University in St Louis, St Louis, MO, USA.
Department of Pathology, Cooper University Health Care, 1 Cooper Plaza, Pavilion Building P065, Camden, NJ, 08103, USA.
Diagn Pathol. 2024 Dec 18;19(1):160. doi: 10.1186/s13000-024-01572-4.
Anogenital mammary-like glands (AGMLGs) are present in the anogenital region that bear striking morphologic and protein-expression similarities to mammary glands in the breast. AGMLGs can give rise to both benign and malignant lesions which mimic primary breast lesions. Herein, we report two mammary-type adenocarcinomas arising from AGMLGs, including one in the previously unreported site of the rectum. Recognition of mammary-type adenocarcinoma in the rectal and anogenital regions is crucial as clinical management options may differ compared to conventional colorectal adenocarcinomas.
肛门生殖器乳腺样腺体（AGMLGs）存在于肛门生殖器区域，在形态学和蛋白质表达方面与乳腺有显著相似之处。AGMLGs可引发良性和恶性病变，这些病变与原发性乳腺病变相似。在此，我们报告两例起源于AGMLGs的乳腺型腺癌，其中一例发生在直肠这个此前未被报道的部位。认识直肠和肛门生殖器区域的乳腺型腺癌至关重要，因为与传统结直肠癌相比，其临床管理方案可能有所不同。
