Meng Hui, He Fang, Hong Lin Xiao, Yan Xianrang, She Xiaolong, Lu Lijuan, Yu Xuetao
Department of Critical Care Medicine, The Second Affiliated Hospital of the Chinese University of Hong Kong, Shenzhen, China.
Department of Health Management, The Second Affiliated Hospital of the Chinese University of Hong Kong, Shenzhen, China.
BMC Infect Dis. 2024 Dec 18;24(1):1445. doi: 10.1186/s12879-024-10278-3.
Gastrointestinal (GI) aspergillosis is a rare and fatal complication in immunocompromised patients. We present the case of a 72-year-old patient with unexplained recurrent pancytopenia who presented with fever, constipation, abdominal distention, and jaundice. Imaging revealed a mass in the ileocecal junction, and biopsy revealed Aspergillus hyphae infiltrating the bowel wall. He had no evidence of pulmonary, sinus, or central nervous system Aspergillus infection. After 1 month of antifungal treatment with oral isavuconazole, he recovered well and was discharged. The clinical manifestations of GI aspergillosis are non-specific. This case highlights the importance of increasing the awareness regarding GI aspergillosis in high-risk patients without pulmonary involvement.
胃肠道曲霉菌病是免疫功能低下患者中一种罕见且致命的并发症。我们报告了一例72岁的患者，该患者患有不明原因的复发性全血细胞减少症，出现发热、便秘、腹胀和黄疸。影像学检查显示回盲部有肿块，活检显示曲霉菌丝浸润肠壁。他没有肺部、鼻窦或中枢神经系统曲霉菌感染的证据。经过1个月的口服艾沙康唑抗真菌治疗后，他恢复良好并出院。胃肠道曲霉菌病的临床表现不具有特异性。该病例凸显了提高对无肺部受累的高危患者胃肠道曲霉菌病认识的重要性。
