Cao Danna, Yue Jinhuan, Wei Zeyi, Huang Dong-Hong, Sun Xuchen, Liu Ke-Xuan, Wang Peng, Jiang Fan, Li Xiaoling, Zhang Qinhong
Division of CT and MRI, First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, China.
Shenzhen Frontiers in Chinese Medicine Research Co., Ltd., Shenzhen, China.
Front Aging Neurosci. 2024 Dec 4;16:1494385. doi: 10.3389/fnagi.2024.1494385. eCollection 2024.
Cognitive impairment is a critical non-motor symptom of Parkinson's Disease (PD) that profoundly affects patients' quality of life. Magnetic Resonance Imaging (MRI) has emerged as a valuable tool for investigating the structural and functional brain changes associated with cognitive impairment in PD (PD-CI). MRI techniques enable the precise identification and monitoring of the onset and progression of cognitive deficits in PD. This review synthesizes recent literature on the use of MRI-based techniques, including voxel-based morphometry, diffusion tensor imaging, and functional MRI, in the study of PD-CI. By examining these imaging modalities, the article aims to elucidate the patterns of brain structural and functional alterations in PD-CI, offering critical insights that can inform clinical management and therapeutic strategies. In particular, this review provides a novel synthesis of recent advancements in understanding how specific MRI metrics, such as amplitude of low-frequency fluctuations, regional homogeneity, and functional connectivity, contribute to early detection and personalized treatment approaches for PD-CI. The integration of findings from these studies enhances our understanding of the neural mechanisms underlying cognitive impairment in PD and highlights the potential of MRI as a supportive tool in the clinical assessment and treatment of PD-CI.
认知障碍是帕金森病（PD）的一种关键非运动症状，严重影响患者的生活质量。磁共振成像（MRI）已成为研究与PD认知障碍（PD-CI）相关的大脑结构和功能变化的重要工具。MRI技术能够精确识别和监测PD中认知缺陷的发生和进展。本综述综合了近期有关基于MRI技术（包括基于体素的形态计量学、扩散张量成像和功能MRI）在PD-CI研究中的应用的文献。通过研究这些成像方式，本文旨在阐明PD-CI中大脑结构和功能改变的模式，提供可指导临床管理和治疗策略的关键见解。特别是，本综述对近期在理解特定MRI指标（如低频波动幅度、局部一致性和功能连接性）如何有助于PD-CI的早期检测和个性化治疗方法方面的进展进行了新颖的综合。这些研究结果的整合增强了我们对PD认知障碍潜在神经机制的理解，并突出了MRI作为PD-CI临床评估和治疗辅助工具的潜力。
