Chen Hui, Li Jing-Jing, Guan Chun-Shuang, Xue Ming, Xing Yu-Xue, Xie Ru-Ming
Department of Radiology, Beijing Ditan Hospital, Capital Medical University, Beijing, People's Republic of China.
Neuropsychiatr Dis Treat. 2024 Dec 14;20:2529-2539. doi: 10.2147/NDT.S484214. eCollection 2024.
To investigate whole-brain gray matter volume (GMV) changes in human immunodeficiency (HIV)-negative patients with general paresis of the insane (GPI) using voxel-based morphometry (VBM).
A total of 18 HIV-negative individuals with GPI and 24 healthy control volunteers matched for sex, age, and education were enrolled in this study. 3 D T1-weighted imaging (3D T1WI) structural images of GPI patients and healthy controls were preprocessed using VBM. The GMV was then segmented and compared between the two groups. In addition, the correlation between cortical/subcortical GMVs and neuropsychological/laboratory test results was analyzed.
Compared to the normal control group, the GPI group showed a decrease in GMV in multiple regions, including the bilateral frontal cortices (superior frontal gyrus, middle frontal gyrus, orbital gyrus), bilateral temporal/occipital cortices (superior temporal, bilateral inferior temporal, bilateral parahippocampal, bilateral cingulate, left precentral, left fusiform, left posterior superior temporal sulcus, left lateral occipital, right middle temporal, right precuneus, right insular, and right medioventral occipital), and right parietal cortices (right superior parietal, right inferior parietal) (p<0.01, FDR corrected). Additionally, there was an increase in GMV in the bilateral basal ganglia, right hippocampus, and bilateral thalamus (p<0.01, FDR corrected). In the GPI group, GMVs of the right rostral hippocampus (r=-0.524, p=0.026), bilateral dorsal caudate nucleus (r=-0.604, p=0.008; r=-0.685, p=0.002), and the right rostral temporal thalamus (r=-0.560, p=0.016) were negatively correlated with MMSE score.
VBM showed that there are structural changes in brain GMV in HIV-negative GPI patients. The use of VBM has the potential to provide a valuable imaging basis for the diagnosis of GPI.
采用基于体素的形态学测量（VBM）方法，研究人类免疫缺陷病毒（HIV）阴性的麻痹性痴呆（GPI）患者的全脑灰质体积（GMV）变化。
本研究共纳入18例HIV阴性的GPI患者以及24名在性别、年龄和教育程度上相匹配的健康对照志愿者。使用VBM对GPI患者和健康对照者的三维T1加权成像（3D T1WI）结构图像进行预处理。然后对两组的GMV进行分割并比较。此外，分析皮质/皮质下GMV与神经心理学/实验室检查结果之间的相关性。
与正常对照组相比，GPI组多个区域的GMV减少，包括双侧额叶皮质（额上回、额中回、眶回）、双侧颞叶/枕叶皮质（颞上回、双侧颞下回、双侧海马旁回、双侧扣带回、左侧中央前回、左侧梭状回、左侧颞上沟后部、左侧枕外侧回、右侧颞中回、右侧楔前回、右侧岛叶、右侧枕内侧腹侧回）以及右侧顶叶皮质（右侧顶上小叶、右侧顶下小叶）（p<0.01，经FDR校正）。此外，双侧基底神经节、右侧海马和双侧丘脑的GMV增加（p<0.01，经FDR校正）。在GPI组中，右侧喙海马（r=-0.524，p=0.026）、双侧背侧尾状核（r=-0.604，p=0.008；r=-0.685，p=0.002）以及右侧喙颞丘脑（r=-0.560，p=0.016）的GMV与简易精神状态检查表（MMSE）评分呈负相关。
VBM显示HIV阴性的GPI患者脑GMV存在结构变化。VBM的应用有可能为GPI的诊断提供有价值的影像学依据。
