Guo Yumei, Cao Yuwen, He Baohua, Dong Xinyan, Bi Meng, Wang Xiaoli, Gao Teng, Liu Xingle, Wang Ke, Wang Yuhao, Zhang Hong, Sun Yinqi, Gao Weili, Zhang Yulan, Jia Zhaoyi
Shijiazhuang Center for Disease Control and Prevention, Hebei Key Laboratory of Intractable Pathogens, Shijiazhuang City, Hebei Province, China.
Hebei Provincial Center for Disease Control and Prevention Bacterial Disease Prevention and Disinfection Institute, Hebei Key Laboratory of Pathogens and Epidemiology of Infectious Diseases, Shijiazhuang City, Hebei Province, China.
China CDC Wkly. 2024 Nov 22;6(47):1242-1247. doi: 10.46234/ccdcw2024.249.
WHAT IS ALREADY KNOWN ABOUT THIS TOPIC?: (Nm) is a bacterial pathogen that causes meningococcal disease. Serogroups A, B, C, W, X, and Y account for the vast majority of cases. However, invasive meningococcal disease (IMD) caused by NmY is rare in China and has been reported only in Tianjin, Guangdong, Shanghai, and Hunan provinces and cities.
WHAT IS ADDED BY THIS REPORT?: This article reports the first case of :cc23 meningococcal disease in Hebei Province, confirmed by metagenomic sequencing. We also present the results of expanded surveillance in the healthy population associated with the case.
WHAT ARE THE IMPLICATIONS FOR PUBLIC HEALTH PRACTICE?: has caused multiple case reports across China, especially in southern cities. The first report of a serogroup Y case in Hebei Province, and the carriage rate in the healthy population, reminds us to increase public health attention on . The results of this study suggest that surveillance of the carriage rate among healthy carriers and serogroup changes in should be strengthened.
关于该主题已知的信息有哪些?:脑膜炎奈瑟菌(Nm)是一种引起脑膜炎球菌病的细菌病原体。A、B、C、W、X和Y血清群占绝大多数病例。然而,由NmY引起的侵袭性脑膜炎球菌病(IMD)在中国很少见,仅在天津、广东、上海和湖南等省市有报告。
本报告新增了哪些内容?:本文报告了河北省首例经宏基因组测序确诊的cc23型脑膜炎球菌病病例。我们还展示了与该病例相关的健康人群扩大监测结果。
对公共卫生实践有何启示?:已在中国各地引发多起病例报告,尤其是在南方城市。河北省首例Y血清群病例报告以及健康人群中的携带率,提醒我们要加强对……的公共卫生关注。本研究结果表明,应加强对健康携带者中……携带率以及……血清群变化的监测。