Zhang Yunyi, Deng Xuan, Jiang Yan, Zhang Junyan, Zhan Li, Mei Lingling, Lu Hangjing, Yao Pingping, He Hanqing
Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, China.
Department of Infectious Diseases, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Front Microbiol. 2022 Jan 24;12:801196. doi: 10.3389/fmicb.2021.801196. eCollection 2021.
() remains a worldwide leading cause of epidemic meningitis. During 2011-July 2021, 55 meningococcal disease (MD) cases were reported with a case fatality rate of 5.45% in Zhejiang Province, China. The median age was 7 years. The annual incidence was 0.0017-0.0183 per 100,000 population. The highest age-specific incidence was observed in the group younger than 1 year. Serogroup was identified in 30 laboratory-confirmed MD cases, and MenB was most predominant. MenB was mainly observed in two age groups: younger than 5 and older than 35 years. MenB incidence was significantly increasing from 0.0018 per 100,000 in 2013 to 0.0070 per 100,000 in 2019. During 2015-2020, 17 positive samples were detected from 2,827 throat swabs from healthy population, of which 70.59% was MenB. Twenty multilocus sequence typing sequence types (STs) containing eight newly assigned STs (ST15881-ST15888) were determined in all isolates. Either in MD cases or in healthy population, MenB CC ST-4821 was the predominant ST. It was worth noting that two MenY CC ST-23 cases occurred in 2019 and 2021, respectively. MenY CC ST-23 MD cases increased gradually in China. Phylogeny results based on genome sequencing indicated that Chinese MenW CC ST-11 isolates were genetically linked and grouped together with Japanese isolates, separated from MenW CC ST-11 isolates from Saudi Arabia Hajj outbreak, Europe, South Africa, South America, North America, and Oceania. MenW CC ST-11 isolates from East Asia might have evolved locally. Antibiotic susceptibility tests revealed a relatively high resistance rate (22.86%) of isolates to penicillin. This study provided valuable data for Chinese public health authorities to grasp the temporal epidemiological characteristics of MD and healthy carriage.
（）仍然是全球流行性脑膜炎的主要病因。2011年至2021年7月期间，中国浙江省报告了55例脑膜炎球菌病（MD）病例，病死率为5.45%。中位年龄为7岁。年发病率为每10万人0.0017至0.0183例。年龄特异性发病率最高的是1岁以下人群。在30例实验室确诊的MD病例中确定了血清群，其中B群脑膜炎奈瑟菌最为常见。B群脑膜炎奈瑟菌主要出现在两个年龄组：5岁以下和35岁以上。B群脑膜炎奈瑟菌发病率从2013年的每10万人0.0018例显著增至2019年的每10万人0.0070例。2015年至2020年期间，从2827份健康人群咽拭子中检测到17份阳性样本，其中70.59%为B群脑膜炎奈瑟菌。在所有分离株中确定了20种多位点序列分型序列类型（STs），其中包括8种新指定的STs（ST15881 - ST15888）。无论是在MD病例还是健康人群中，B群脑膜炎奈瑟菌复合群ST - 4821都是主要的ST。值得注意的是，2019年和2021年分别出现了2例Y群脑膜炎奈瑟菌复合群ST - 23病例。Y群脑膜炎奈瑟菌复合群ST - 23的MD病例在中国逐渐增加。基于基因组测序的系统发育结果表明，中国的W群脑膜炎奈瑟菌复合群ST - 11分离株在基因上相互关联，并与日本分离株归为一组，与来自沙特阿拉伯朝觐疫情、欧洲、南非、南美洲、北美洲和大洋洲的W群脑膜炎奈瑟菌复合群ST - 11分离株分开。东亚的W群脑膜炎奈瑟菌复合群ST - 11分离株可能在当地进化。抗生素敏感性试验显示，分离株对青霉素的耐药率相对较高（22.86%）。本研究为中国公共卫生当局掌握MD和健康带菌的时间流行病学特征提供了有价值的数据。
