Han Meng, Pang Bairen, Zhou Cheng, Li Xin, Wang Qi, Jiang Junhui, Li Yong
Translational Research Laboratory for Urology, the Key Laboratory of Ningbo City, Ningbo First Hospital, The Affiliated Hospital of Ningbo University, Ningbo 315600, Zhejiang, China.
Ningbo Clinical Research Center for Urological Disease, Ningbo 315600, Zhejiang, China.
Extracell Vesicles Circ Nucl Acids. 2022 Jan 13;3(1):3-9. doi: 10.20517/evcna.2021.20. eCollection 2022.
Liquid biopsy of tumor-derived extracellular vesicles (EVs) has great potential as a biomarker source for prostate cancer (CaP) early diagnosis and predicting the stages of cancer. The contents of EVs play an important role in intercellular communication and have specific expression in blood and urine samples from CaP patients. Powered by high-throughput, next-generation sequencing and proteomic technologies, novel EV biomarkers are easily detected in a non-invasive manner in different stages of CaP patients. These identified potential biomarkers can be further validated with a large sample size, machine learning model, and other different methods to improve the sensitivity and specificity of CaP diagnosis. The EV-based liquid biopsy is a novel and less-invasive alternative to surgical biopsies which would enable clinicians to potentially discover a whole picture of tumor through a simple blood or urine sample. In summary, this approach holds promise for developing personalized medicine to guide treatment decisions precisely for CaP patients.
肿瘤衍生细胞外囊泡（EVs）的液体活检作为前列腺癌（CaP）早期诊断和预测癌症分期的生物标志物来源具有巨大潜力。细胞外囊泡的内容物在细胞间通讯中起重要作用，并且在CaP患者的血液和尿液样本中具有特异性表达。借助高通量、新一代测序和蛋白质组学技术，新型细胞外囊泡生物标志物能够以非侵入性方式在CaP患者的不同阶段轻松检测到。这些已鉴定出的潜在生物标志物可以通过大样本量、机器学习模型和其他不同方法进一步验证，以提高CaP诊断的敏感性和特异性。基于细胞外囊泡的液体活检是手术活检的一种新型且侵入性较小的替代方法，它使临床医生能够通过简单的血液或尿液样本潜在地发现肿瘤的全貌。总之，这种方法有望开发个性化医疗，为CaP患者精确指导治疗决策。
