Izquierdo-Altarejos Paula, Felipo Vicente
Laboratory of Neurobiology, Príncipe Felipe Research Centre, Valencia 46012, Spain.
Extracell Vesicles Circ Nucl Acids. 2024 Jan 17;5(1):37-43. doi: 10.20517/evcna.2023.66. eCollection 2024.
Cirrhotic patients can present hepatic encephalopathy (HE), showing motor and cognitive deficits. Hyperammonemia and peripheral inflammation are known to induce neuroinflammation and alter neurotransmission, which finally induces neurological impairment in HE. However, the mechanisms by which the deleterious effects of peripheral inflammation are transmitted to the brain are not well understood. Extracellular vesicles (EVs) have recently emerged as a new mediator between the periphery and the brain, particularly in pathologies associated with sustained inflammation and in neurological disorders. In this work, we summarized the main findings on the role of plasma EVs in hyperammonemia and HE and discussed its potential implication in the pathogenesis of hepatic encephalopathy.
肝硬化患者可出现肝性脑病（HE），表现为运动和认知功能障碍。已知高氨血症和外周炎症会诱发神经炎症并改变神经传递，最终导致肝性脑病的神经功能损害。然而，外周炎症的有害作用传递至大脑的机制尚不清楚。细胞外囊泡（EVs）最近已成为外周与大脑之间的一种新介质，尤其是在与持续性炎症相关的疾病和神经疾病中。在这项工作中，我们总结了血浆细胞外囊泡在高氨血症和肝性脑病中的作用的主要发现，并讨论了其在肝性脑病发病机制中的潜在意义。
