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黑人与白人患者胰腺导管腺癌的分子差异

Molecular Differences in Pancreatic Ductal Adenocarcinomas from Black versus White Patients.

作者信息

Mandal Saurabh, Teslow Emily A, Huang Minxuan, Yu Yingying, Sridhar Swathi, Crawford Howard C, Hockenberry Adam J, Stoppler Melissa C, Levin Albert M, Huang Ling

机构信息

Henry Ford Pancreatic Cancer Center, Henry Ford Health, Detroit, Michigan.

Tempus AI, Inc., Chicago, Illinois.

出版信息

Cancer Res Commun. 2025 Jan 1;5(1):128-137. doi: 10.1158/2767-9764.CRC-24-0376.

DOI:10.1158/2767-9764.CRC-24-0376
PMID:39699266
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11752082/
Abstract

By analyzing the records of patients with pancreatic cancer in the Tempus multimodal database, we identified genomic mutations and PD-L1 overexpression occurred more frequently in Black patients compared with their White counterparts. These molecular features may contribute to racial disparities in pancreatic cancer.

摘要

通过分析Tempus多模态数据库中胰腺癌患者的记录，我们发现与白人患者相比，黑人患者的基因变异和程序性死亡受体配体1（PD-L1）过表达更为常见。这些分子特征可能导致胰腺癌的种族差异。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4fd5/11752082/7abbe20a7c5f/crc-24-0376_f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4fd5/11752082/47844a6c632a/crc-24-0376_f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4fd5/11752082/87f49ac66e8c/crc-24-0376_f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4fd5/11752082/7abbe20a7c5f/crc-24-0376_f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4fd5/11752082/47844a6c632a/crc-24-0376_f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4fd5/11752082/87f49ac66e8c/crc-24-0376_f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4fd5/11752082/7abbe20a7c5f/crc-24-0376_f3.jpg

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本文引用的文献

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Additional impact of genetic ancestry over race/ethnicity to prevalence of KRAS mutations and allele-specific subtypes in non-small cell lung cancer.遗传背景对非小细胞肺癌 KRAS 突变及等位基因特异性亚型发生率的影响超过种族/民族因素。
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