Silva Lucas Marques Soares da, Gomes Eleni Solange de Brito, Vieira Julia Hailer, Aguiar Murilo Porfírio de, Silva Saulo Fernando Moreira da, Michelin Marcia Antoniazi
Instituto de Pesquisa em Oncologia, Universidade Federal do Triângulo Mineiro, Uberaba, MG, Brazil.
Universidade Federal do Triângulo Mineiro, Uberaba, MG, Brazil.
Einstein (Sao Paulo). 2024 Dec 16;22:eRW0935. doi: 10.31744/einstein_journal/2024RW0935. eCollection 2024.
This integrative review article examines the efficacy of adoptive cell therapy using tumor-infiltrating lymphocytes, with a particular focus on the treatment of melanomas and other solid tumors.
The methodology encompasses theme definition, comprehensive database searches, and a critical review of pertinent literature. Of the 1,947 articles initially identified, 15 were meticulously selected based on stringent inclusion and exclusion criteria.
The findings suggest that tumor-infiltrating lymphocytes-based therapy is particularly effective in treating metastatic melanomas, as noted by its tailored approach and substantial potential. However, the applicability of these findings to other solid tumor types remains limited.
This review indicates that adoptive cell therapy using tumor-infiltrating lymphocytes demonstrates efficacy, especially in the treatment of metastatic melanoma, and shows considerable promise for treating solid tumors.
这篇综合性综述文章探讨了使用肿瘤浸润淋巴细胞的过继性细胞疗法的疗效，特别关注黑色素瘤和其他实体瘤的治疗。
该方法包括主题定义、全面的数据库检索以及对相关文献的批判性综述。在最初确定的1947篇文章中，根据严格的纳入和排除标准精心挑选了15篇。
研究结果表明，基于肿瘤浸润淋巴细胞的疗法在治疗转移性黑色素瘤方面特别有效，其定制化方法和巨大潜力值得关注。然而，这些发现对其他实体瘤类型的适用性仍然有限。
本综述表明，使用肿瘤浸润淋巴细胞的过继性细胞疗法显示出疗效，尤其是在治疗转移性黑色素瘤方面，并且在治疗实体瘤方面显示出相当大的前景。
