丙戊酸、左乙拉西坦、卡马西平和奥卡西平对儿童甲状腺功能检查的影响。
Effects of valproic acid, levetiracetam, carbamazepine, and oxcarbazepine on thyroid function tests in children.
作者信息
Güngör Olcay, Yüzbaşı Beste Kipçak, Özhan Bayram, Orhan Onur, Şevik Rümeysa, Güngör Gülay
机构信息
Pamukkale University, School of Medicine, Department of Pediatric Neurology - Denizli, Turkey.
Pamukkale University, School of Medicine, Department of Pediatric Endocrinology - Denizli, Turkey.
出版信息
Rev Assoc Med Bras (1992). 2024 Dec 16;70(12):e20241177. doi: 10.1590/1806-9282.20241177. eCollection 2024.
OBJECTIVE
The aim of the study was to evaluate the effects of commonly used medications for epilepsy on thyroid function tests in children.
METHODS
Epileptic children treated with valproic acid, levetiracetam, carbamazepine, and oxcarbazepine were retrospectively examined along with a healthy control group. Levels of free thyroxine 4 and thyroid-stimulating hormone were compared.
RESULTS
In patients receiving valproic acid monotherapy, thyroid-stimulating hormone levels increased compared to both the control group and pre-treatment levels, while free thyroxine 4 levels remained unchanged. In those receiving carbamazepine or oxcarbazepine monotherapy, average free thyroxine 4 levels were found to be lower compared to the control group and pre-treatment levels, with no difference in thyroid-stimulating hormone levels. For patients receiving levetiracetam monotherapy, there was no difference in free thyroxine 4 and thyroid-stimulating hormone levels compared to the control group and pre-treatment levels.
CONCLUSION
Despite significant changes in thyroid hormone levels with valproic acid, carbamazepine, and oxcarbazepine treatment, no significant clinical findings were observed. Additionally, no effect of levetiracetam on thyroid function tests was detected.
目的
本研究旨在评估常用抗癫痫药物对儿童甲状腺功能检查的影响。
方法
对接受丙戊酸、左乙拉西坦、卡马西平和奥卡西平治疗的癫痫患儿以及健康对照组进行回顾性检查。比较游离甲状腺素4和促甲状腺激素水平。
结果
接受丙戊酸单药治疗的患者，与对照组和治疗前水平相比，促甲状腺激素水平升高，而游离甲状腺素4水平保持不变。接受卡马西平或奥卡西平单药治疗的患者，与对照组和治疗前水平相比，平均游离甲状腺素4水平较低，促甲状腺激素水平无差异。接受左乙拉西坦单药治疗的患者，与对照组和治疗前水平相比，游离甲状腺素4和促甲状腺激素水平无差异。
结论
尽管丙戊酸、卡马西平和奥卡西平治疗后甲状腺激素水平有显著变化，但未观察到明显的临床症状。此外，未检测到左乙拉西坦对甲状腺功能检查有影响。
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