Puga Troy B, Doucet Gaelle E, Thiel Grace E, Theye Elijah, Dai Hongying Daisy
College of Public Health, University of Nebraska Medical Center, Omaha.
College of Osteopathic Medicine, Kansas City University, Kansas City, Missouri.
JAMA Netw Open. 2024 Dec 2;7(12):e2451786. doi: 10.1001/jamanetworkopen.2024.51786.
Maternal tobacco use during pregnancy (MTDP) remains a major public health challenge. However, the complete spectrum of effects of MTDP is not fully understood.
To examine the longitudinal associations of MTDP and children's brain morphometric subcortical volume and gray-white matter contrast (GWC) development.
DESIGN, SETTING, AND PARTICIPANTS: Cohort study of children aged 9 to 10 years at wave 1 (October 2016 to October 2018) and at a 2-year follow-up (wave 2; August 2018 to January 2021; aged 11-12 years) across 21 US sites in the Adolescent Brain Cognitive Development (ABCD) Study. Data were analyzed from October 2023 to October 2024.
MTDP.
Morphometric brain measures of subcortical volume and GWC.
Among the 11 448 children (51.5% male; 13.1% Black; 24.0% Hispanic; and 52.9% White) at wave 1, 1607 (16.6%; 95% CI, 13.0%-20.2%) were identified with MTDP exposure. At wave 1, children with MTDP exposure (vs no exposure) exhibited lower GWC in widespread brain regions primarily located in the frontal (eg, superior frontal; regression coefficient [B] = -0.0019; SE, 0.0006; P = .004), parietal (eg, supramarginal; B = -0.0021; SE, 0.0007; P = .002) and temporal lobes (eg, middle temporal; B = -0.0024; SE, 0.0007; P < .001). These differences in GWC continued to be significant at wave 2. In regard to subcortical volume, children with MTDP exposure demonstrated smaller volume of the lateral ventricle (B = -257.5; SE, 78.6; P = .001) and caudate (B = -37.7; SE, 14.0; P = .01) in the left hemisphere at wave 1, and lower volume of the caudate in both left (B = -48.7; SE, 15.9; P = .002) and right hemisphere (B = -45.5; SE, 16.1; P = .01) at wave 2.
This cohort study found that MTDP exposure was associated with lower GWC across the whole cortex and smaller caudate nuclei volume compared with no exposure, signifying the importance of preventing MTDP and necessitating further research on this topic.
孕期母亲吸烟（MTDP）仍然是一项重大的公共卫生挑战。然而，MTDP的全部影响范围尚未完全明确。
研究MTDP与儿童脑形态学皮质下体积及灰白质对比度（GWC）发育之间的纵向关联。
设计、背景和参与者：对青少年大脑认知发育（ABCD）研究中美国21个地点的9至10岁儿童（第1波，2016年10月至2018年10月）及其2年随访（第2波，2018年8月至2021年1月；11至12岁）进行队列研究。数据于2023年10月至2024年10月进行分析。
MTDP。
脑形态学测量的皮质下体积和GWC。
在第1波的11448名儿童（51.5%为男性；13.1%为黑人；24.0%为西班牙裔；52.9%为白人）中，1607名（16.6%；95%CI，13.0%-20.2%）被确定有MTDP暴露。在第1波时，有MTDP暴露的儿童（与无暴露儿童相比）在广泛的脑区表现出较低的GWC，这些脑区主要位于额叶（如额上回；回归系数[B]=-0.0019；标准误，0.0006；P=0.004）、顶叶（如缘上回；B=-0.0021；标准误，0.0007；P=0.002）和颞叶（如颞中回；B=-0.0024；标准误，0.0007；P<0.001）。这些GWC差异在第2波时仍然显著。关于皮质下体积，有MTDP暴露的儿童在第1波时左半球侧脑室体积较小（B=-257.5；标准误，78.6；P=0.001）和尾状核体积较小（B=-37.7；标准误，14.0；P=0.01），在第2波时左半球（B=-48.7；标准误，15.9；P=0.002）和右半球（B=-45.5；标准误，16.1；P=0.01）的尾状核体积也较小。
这项队列研究发现，与无暴露相比，MTDP暴露与全皮质较低的GWC和较小的尾状核体积相关，这表明预防MTDP的重要性，并需要对此主题进行进一步研究。
