Azeredo Thaís de Lima, Freitas Laíze Rosa Pires, Soares Rodrigo Villamarim, Oliveira Dauro Douglas, Visconti Maria Augusta, Villoria Eduardo Murad
Universidade Federal do Rio de Janeiro, Faculdade de Odontologia, Departamento de Patologia e Diagnóstico Oral (Rio de Janeiro, RJ, Brazil).
Private practice (Belo Horizonte/MG, Brazil).
Dental Press J Orthod. 2024 Dec 16;29(6):e242496. doi: 10.1590/2177-6709.29.6.e242496.oar. eCollection 2024.
The early diagnosis of mandibular asymmetry (MA) in patients with unilateral cleft lip and palate (UCLP) can contribute to its treatment.
The aim of this study was to evaluate the occurrence and the extent of MA in UCLP patients at different growth stages.
Cone-beam computed tomography (CBCT) of 47 UCLP patients were included, and divided into two groups (prepubertal stage and pubertal stage). The mandibular ramus height (Co-Go), mandibular body length (Go-Me), total mandibular length (Co-Me), gonial angle (CoGoMe), the volume of the mandibular condyles, and lateral chin deviation were evaluated. The cleft side (CS) and noncleft side (NCS) were compared using the paired t-test for dependent samples. Chin deviation and its possible association with specific sides were evaluated using the Mann-Whitney and Fisher's Exact tests, respectively. The significance level was set at 5%.
Comparison of CS and NCS revealed that in prepubertal stage, Co-Me was shorter (105.5 ± 5.7 mm; p = 0.036) in the CS, and that in pubertal stage, Co-Go was lower (46 ± 6 mm; p= 0.004) and Go-Me was greater (78.5 ± 5.8 mm; p = 0.026) in the CS. In both growth stages, a significant association (p< 0.05) was observed between the side to which the chin has deviated and the CS.
Although patients with UCLP in the prepubertal and pubertal stages presented significant measurements revealing MA, only Co-Go in the pubertal stage showed a clinically relevant difference. This specific result indicates that MA must be monitored during patients' growth.
单侧唇腭裂（UCLP）患者下颌不对称（MA）的早期诊断有助于其治疗。
本研究旨在评估不同生长阶段UCLP患者MA的发生率和程度。
纳入47例UCLP患者的锥形束计算机断层扫描（CBCT），并分为两组（青春期前阶段和青春期阶段）。评估下颌升支高度（Co-Go）、下颌体长（Go-Me）、下颌总长度（Co-Me）、下颌角（CoGoMe）、下颌髁突体积和颏部侧方偏斜。使用配对t检验对相关样本比较裂侧（CS）和非裂侧（NCS）。分别使用Mann-Whitney检验和Fisher精确检验评估颏部偏斜及其与特定侧别的可能关联。显著性水平设定为5%。
CS与NCS的比较显示，在青春期前阶段，CS侧的Co-Me较短（105.5±5.7mm；p=0.036），而在青春期阶段，CS侧的Co-Go较低（46±6mm；p=0.004）且Go-Me较长（78.5±5.8mm；p=0.026）。在两个生长阶段，均观察到颏部偏斜的侧别与CS之间存在显著关联（p<0.05）。
尽管青春期前和青春期阶段的UCLP患者表现出显著测量结果显示存在MA，但仅青春期阶段的Co-Go显示出临床相关差异。这一特定结果表明，在患者生长过程中必须监测MA。
