Losch Merle S, Visser Benjamin E, Dankelman Jenny, Hendriks Benno H W
Department of Biomechanical Engineering, Faculty of Mechanical Engineering, Delft University of Technology, Delft, The Netherlands.
Philips Medical Systems Nederland B.V., Best, The Netherlands.
PLoS One. 2024 Dec 19;19(12):e0314706. doi: 10.1371/journal.pone.0314706. eCollection 2024.
The demographic shift has increased the demand for surgical interventions to address age-related degenerative diseases, such as spinal fusion. Accurate placement of pedicle screws, crucial for successful spinal fusion, varies widely with physician experience. Integrating tissue sensing into spine surgical instruments allows intraoperative examination of tissue properties, providing surgeons with additional information to prevent screw misplacement. This paper introduces a handheld fiber-optic tissue sensing device for real-time bone tissue differentiation during spine surgery using Diffuse Reflectance Spectroscopy (DRS). Our prototype employs laser diodes at two distinct wavelengths for tissue illumination, eliminating the need for a spectrometer and enabling direct light collection with a photodiode. The device includes a printed circuit board (PCB) with driver circuits that are adjustable for varying laser diode output power, and signal amplification to convert the photodiode current to a measurable voltage signal. Controlled by a microcontroller, the device computes a reflectance ratio from both laser diode signals to provide real-time audio feedback to surgeons across various healthcare settings. Despite challenges in coupling efficiencies from manual fiber-coupling of the diodes, our prototype is able to emit and collect light to distinguish bone tissues with DRS, demonstrating feasibility. It is compact, made of low-cost and readily available components, and offers fast, real-time feedback, thus serving as a successful proof-of-concept for enhancing surgical accuracy during spinal fusion procedures.
人口结构的变化增加了对手术干预的需求,以应对与年龄相关的退行性疾病,如脊柱融合术。椎弓根螺钉的准确置入对于脊柱融合术的成功至关重要,但因医生经验不同而差异很大。将组织传感集成到脊柱手术器械中可在术中检查组织特性,为外科医生提供额外信息以防止螺钉误置。本文介绍了一种手持式光纤组织传感设备,用于在脊柱手术期间使用漫反射光谱(DRS)进行实时骨组织鉴别。我们的原型采用两个不同波长的激光二极管进行组织照明,无需光谱仪,并可通过光电二极管直接收集光线。该设备包括一个带有驱动电路的印刷电路板(PCB),驱动电路可调节以改变激光二极管的输出功率,并进行信号放大,将光电二极管电流转换为可测量的电压信号。由微控制器控制,该设备计算两个激光二极管信号的反射率比,为不同医疗环境中的外科医生提供实时音频反馈。尽管在二极管的手动光纤耦合方面存在耦合效率的挑战,但我们的原型能够发射和收集光线,通过DRS区分骨组织,证明了其可行性。它体积紧凑,由低成本且易于获得的组件制成,并提供快速的实时反馈,因此作为在脊柱融合手术中提高手术准确性的成功概念验证。