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妊娠合并粟粒性肺结核的一个具有挑战性的病例。

A Challenging Case of Miliary Tuberculosis in Pregnancy.

作者信息

Singh Anuja, Siddiqui Farha, Maurya Anand Kumar, Purwar Shashank, Saigal Saurabh

机构信息

Department of Microbiology, AIIMS, Bhopal, Madhya Pradesh, India.

Department of Anaesthesiology, AIIMS, Bhopal, Madhya Pradesh, India.

出版信息

Int J Mycobacteriol. 2024 Oct 1;13(4):448-451. doi: 10.4103/ijmy.ijmy_216_24. Epub 2024 Dec 19.

DOI:10.4103/ijmy.ijmy_216_24
PMID:39700168
Abstract

Miliary tuberculosis (TB) is an uncommon yet severe condition that can pose substantial risks to pregnant women and their unborn child. This case study describes a 22-year-old pregnant female at 23 weeks of gestation presented with breathlessness, fever accompanied by chills, dry cough, and loss of appetite. With no significant comorbidities, her initial symptoms were inconclusive, leading to her initial diagnosis as a case of pyrexia of unknown origin. Despite receiving iron supplements for anemia and broad-spectrum antibiotics, her health continued to decline, prompting her transfer to a specialized medical center where advanced molecular testing ultimately confirmed a diagnosis of miliary TB. Upon admission, she was promptly started on anti-TB therapy and managed in the intensive care unit, where her clinical course included the development of acute respiratory distress syndrome (ARDS) requiring ventilatory support. Through meticulous monitoring and multidisciplinary intervention, the patient stabilized and ultimately delivered a healthy baby girl through normal vaginal delivery. Miliary TB, though rare, is challenging to diagnose during pregnancy due to overlapping symptoms with other conditions. This case underscores the critical importance of recognizing the atypical presentations of miliary TB in pregnant women, particularly in the context of previous exposure. It highlights the need for high clinical suspicion, timely diagnosis, and comprehensive management strategies to ensure favorable outcomes for both mother and child in the face of such challenging clinical scenarios.

摘要

粟粒性肺结核是一种罕见但严重的疾病,会给孕妇及其未出生的孩子带来重大风险。本病例研究描述了一名22岁、妊娠23周的孕妇,出现呼吸急促、发热伴寒战、干咳和食欲不振。她没有明显的合并症,最初症状不明确,最初被诊断为不明原因发热。尽管接受了治疗贫血的铁补充剂和广谱抗生素治疗,她的健康状况仍持续恶化,促使她被转至一家专业医疗中心,在那里先进的分子检测最终确诊为粟粒性肺结核。入院后,她立即开始接受抗结核治疗,并在重症监护病房接受治疗,其临床病程包括发展为需要通气支持的急性呼吸窘迫综合征(ARDS)。通过精心监测和多学科干预,患者病情稳定,最终通过正常阴道分娩产下一名健康女婴。粟粒性肺结核虽然罕见,但由于其症状与其他疾病重叠,在孕期诊断具有挑战性。本病例强调了认识孕妇粟粒性肺结核非典型表现的至关重要性,尤其是在既往有接触史的情况下。它凸显了面对此类具有挑战性的临床情况时,需要高度的临床怀疑、及时诊断和全面的管理策略,以确保母婴获得良好结局。

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