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Pathogenic T-cell clones in axial spondyloarthritis: what is the evidence?轴性脊柱关节炎中的致病性T细胞克隆：证据有哪些？
Rheumatology (Oxford). 2024 Dec 1;63(Supplement_2):ii4-ii6. doi: 10.1093/rheumatology/keae522.
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Golimumab retention in patients with psoriatic arthritis and axial spondyloarthritis: evidence from up to a decade of follow-up.戈利木单抗在银屑病关节炎和轴性脊柱关节炎患者中的留存率：长达十年随访的证据
Expert Rev Clin Pharmacol. 2025 May;18(5):313-322. doi: 10.1080/17512433.2025.2508960. Epub 2025 May 19.
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Recent Advances in the Immunopathology of Axial Spondyloarthritis: with and without HLA-B27.轴性脊柱关节炎免疫病理学的最新进展：伴和不伴 HLA - B27
Curr Rheumatol Rep. 2025 Jun 21;27(1):27. doi: 10.1007/s11926-025-01194-9.
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Etanercept for treating axial spondyloarthritis.依那西普用于治疗中轴型脊柱关节炎。
Expert Opin Biol Ther. 2017 Sep;17(9):1173-1181. doi: 10.1080/14712598.2017.1347156. Epub 2017 Jul 6.
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Neutrophil-Lymphocyte Ratio in Fibromyalgia and Axial Spondyloarthritis: A Potential Biomarker for Diagnosis and Disease Activity.纤维肌痛和轴性脊柱关节炎中的中性粒细胞与淋巴细胞比值：一种用于诊断和疾病活动度的潜在生物标志物
Biomedicines. 2025 Jun 18;13(6):1497. doi: 10.3390/biomedicines13061497.
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Using Radiofrequency Echographic Multi-spectrometry in the Follow-Up of Patients With Axial Spondyloarthritis and Psoriatic Arthritis.在轴性脊柱关节炎和银屑病关节炎患者随访中使用射频超声多光谱分析技术
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Tapering biologics in axial spondyloarthritis: A systematic literature review.轴向型脊柱关节炎中生物制剂的逐渐减量：系统文献回顾。
Int Immunopharmacol. 2022 Nov;112:109256. doi: 10.1016/j.intimp.2022.109256. Epub 2022 Sep 20.
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Clinical and genetic determinants of worse sexual experience in male patients with radiographic axial spondyloarthritis: a multimodal study.影像学轴向型脊柱关节炎男性患者性体验较差的临床和遗传决定因素：一项多模式研究
RMD Open. 2025 Jun 25;11(2):e005594. doi: 10.1136/rmdopen-2025-005594.
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Cardiovascular risk in axial spondyloarthritis-a systematic review.轴性脊柱关节炎的心血管风险：系统综述。
Clin Rheumatol. 2023 Oct;42(10):2621-2633. doi: 10.1007/s10067-023-06655-z. Epub 2023 Jul 7.
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An Immunosenescent CD8+ T Cell Subset in Patients with Axial Spondyloarthritis and Psoriatic Arthritis Links Spontaneous Motility to Telomere Shortening and Dysfunction.强直性脊柱炎和银屑病关节炎患者中的一种免疫衰老CD8+T细胞亚群将自发运动与端粒缩短和功能障碍联系起来。
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本文引用的文献
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Targeted depletion of TRBV9 T cells as immunotherapy in a patient with ankylosing spondylitis.靶向耗竭 TRBV9 T 细胞作为一名强直性脊柱炎患者的免疫疗法。
Nat Med. 2023 Nov;29(11):2731-2736. doi: 10.1038/s41591-023-02613-z. Epub 2023 Oct 23.
2
Autoimmunity-associated T cell receptors recognize HLA-B*27-bound peptides.自身免疫相关 T 细胞受体识别 HLA-B*27 结合肽。
Nature. 2022 Dec;612(7941):771-777. doi: 10.1038/s41586-022-05501-7. Epub 2022 Dec 7.
3
Antigen-specific immune reactions by expanded CD8 T cell clones from HLA-B*27-positive patients with spondyloarthritis.来自HLA - B*27阳性脊柱关节炎患者的扩增CD8 T细胞克隆的抗原特异性免疫反应。
J Autoimmun. 2022 Dec;133:102901. doi: 10.1016/j.jaut.2022.102901. Epub 2022 Sep 15.
4
Altered Repertoire Diversity and Disease-Associated Clonal Expansions Revealed by T Cell Receptor Immunosequencing in Ankylosing Spondylitis Patients.强直性脊柱炎患者 T 细胞受体免疫测序揭示的受体库多样性改变和与疾病相关的克隆扩增。
Arthritis Rheumatol. 2020 Aug;72(8):1289-1302. doi: 10.1002/art.41252. Epub 2020 Jul 13.
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CD8+ T cells with characteristic T cell receptor beta motif are detected in blood and expanded in synovial fluid of ankylosing spondylitis patients.在强直性脊柱炎患者的血液和滑液中检测到具有特征性 T 细胞受体β基序的 CD8+ T 细胞，并在其中扩增。
Rheumatology (Oxford). 2018 Jun 1;57(6):1097-1104. doi: 10.1093/rheumatology/kex517.
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Discovery of T Cell Receptor β Motifs Specific to HLA-B27-Positive Ankylosing Spondylitis by Deep Repertoire Sequence Analysis.通过深度免疫受体谱序列分析发现 HLA-B27 阳性强直性脊柱炎的 T 细胞受体β基序。
Arthritis Rheumatol. 2017 Apr;69(4):774-784. doi: 10.1002/art.40028.
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Genetics of ankylosing spondylitis--insights into pathogenesis.强直性脊柱炎的遗传学——发病机制的研究进展。
Nat Rev Rheumatol. 2016 Feb;12(2):81-91. doi: 10.1038/nrrheum.2015.133. Epub 2015 Oct 6.
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Conserved TCR beta chain usage in reactive arthritis; evidence for selection by a putative HLA-B27-associated autoantigen.反应性关节炎中保守的TCRβ链使用情况；由一种假定的HLA - B27相关自身抗原进行选择的证据。
Tissue Antigens. 2002 Oct;60(4):299-308. doi: 10.1034/j.1399-0039.2002.600404.x.
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Cell-surface expression and immune receptor recognition of HLA-B27 homodimers.HLA - B27 同型二聚体的细胞表面表达及免疫受体识别
Arthritis Rheum. 2002 Nov;46(11):2972-82. doi: 10.1002/art.10605.
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Epitope specificity of clonally expanded populations of CD8+ T cells found within the joints of patients with inflammatory arthritis.在炎症性关节炎患者关节内发现的克隆扩增CD8 + T细胞群体的表位特异性。
Arthritis Rheum. 2001 Sep;44(9):2038-45. doi: 10.1002/1529-0131(200109)44:9<2038::AID-ART353>3.0.CO;2-1.
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