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Targeted depletion of TRBV9 T cells as immunotherapy in a patient with ankylosing spondylitis.靶向耗竭 TRBV9 T 细胞作为一名强直性脊柱炎患者的免疫疗法。
Nat Med. 2023 Nov;29(11):2731-2736. doi: 10.1038/s41591-023-02613-z. Epub 2023 Oct 23.
2
Autoimmunity-associated T cell receptors recognize HLA-B*27-bound peptides.自身免疫相关 T 细胞受体识别 HLA-B*27 结合肽。
Nature. 2022 Dec;612(7941):771-777. doi: 10.1038/s41586-022-05501-7. Epub 2022 Dec 7.
3
Antigen-specific immune reactions by expanded CD8 T cell clones from HLA-B*27-positive patients with spondyloarthritis.来自HLA - B*27阳性脊柱关节炎患者的扩增CD8 T细胞克隆的抗原特异性免疫反应。
J Autoimmun. 2022 Dec;133:102901. doi: 10.1016/j.jaut.2022.102901. Epub 2022 Sep 15.
4
Altered Repertoire Diversity and Disease-Associated Clonal Expansions Revealed by T Cell Receptor Immunosequencing in Ankylosing Spondylitis Patients.强直性脊柱炎患者 T 细胞受体免疫测序揭示的受体库多样性改变和与疾病相关的克隆扩增。
Arthritis Rheumatol. 2020 Aug;72(8):1289-1302. doi: 10.1002/art.41252. Epub 2020 Jul 13.
5
CD8+ T cells with characteristic T cell receptor beta motif are detected in blood and expanded in synovial fluid of ankylosing spondylitis patients.在强直性脊柱炎患者的血液和滑液中检测到具有特征性 T 细胞受体β基序的 CD8+ T 细胞，并在其中扩增。
Rheumatology (Oxford). 2018 Jun 1;57(6):1097-1104. doi: 10.1093/rheumatology/kex517.
6
Discovery of T Cell Receptor β Motifs Specific to HLA-B27-Positive Ankylosing Spondylitis by Deep Repertoire Sequence Analysis.通过深度免疫受体谱序列分析发现 HLA-B27 阳性强直性脊柱炎的 T 细胞受体β基序。
Arthritis Rheumatol. 2017 Apr;69(4):774-784. doi: 10.1002/art.40028.
7
Genetics of ankylosing spondylitis--insights into pathogenesis.强直性脊柱炎的遗传学——发病机制的研究进展。
Nat Rev Rheumatol. 2016 Feb;12(2):81-91. doi: 10.1038/nrrheum.2015.133. Epub 2015 Oct 6.
8
Conserved TCR beta chain usage in reactive arthritis; evidence for selection by a putative HLA-B27-associated autoantigen.反应性关节炎中保守的TCRβ链使用情况；由一种假定的HLA - B27相关自身抗原进行选择的证据。
Tissue Antigens. 2002 Oct;60(4):299-308. doi: 10.1034/j.1399-0039.2002.600404.x.
9
Cell-surface expression and immune receptor recognition of HLA-B27 homodimers.HLA - B27 同型二聚体的细胞表面表达及免疫受体识别
Arthritis Rheum. 2002 Nov;46(11):2972-82. doi: 10.1002/art.10605.
10
Epitope specificity of clonally expanded populations of CD8+ T cells found within the joints of patients with inflammatory arthritis.在炎症性关节炎患者关节内发现的克隆扩增CD8 + T细胞群体的表位特异性。
Arthritis Rheum. 2001 Sep;44(9):2038-45. doi: 10.1002/1529-0131(200109)44:9<2038::AID-ART353>3.0.CO;2-1.

Pathogenic T-cell clones in axial spondyloarthritis: what is the evidence?

作者信息

Penkava Frank, Sansom Stephen, Bowness Paul

机构信息

Nuffield Department of Orthopedics, Rheumatology and Musculoskeletal Sciences, Oxford University, Oxford, UK.

出版信息

Rheumatology (Oxford). 2024 Dec 1;63(Supplement_2):ii4-ii6. doi: 10.1093/rheumatology/keae522.

DOI:10.1093/rheumatology/keae522
PMID:39700471
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11658411/
Abstract
摘要