从感染伯氏疟原虫的红细胞体外释放的可溶性抗原。
Soluble antigens released in vitro from erythrocytes infected with Plasmodium berghei.
作者信息
Weissberger H, Golenser J, Spira D T
出版信息
Bull World Health Organ. 1979;57 Suppl 1(Suppl):83.
Rat erythrocytes parasitized with Plasmodium berghei were found to release soluble antigenic products in vitro. The supernatants obtained by centrifugation of the disrupted cells induced specific transformation of non-adherent spleen lymphocytes of convalescent rats and produced precipitation lines with antiplasmodial antibodies. In a preliminary experiment they also immunized young rats against a viable challenge of P. berghei. It is suggested that the soluble material could serve for the purification of an effective protective antigen.
发现感染了伯氏疟原虫的大鼠红细胞在体外会释放可溶性抗原产物。通过离心破碎细胞获得的上清液可诱导恢复期大鼠非贴壁脾淋巴细胞发生特异性转化，并与抗疟原虫抗体产生沉淀线。在一项初步实验中，这些上清液还能使幼鼠对伯氏疟原虫的活攻击产生免疫。有人提出，这种可溶性物质可用于纯化一种有效的保护性抗原。
Zotero 插件