Siepmann Ellen Cristina, Agnol Gianezini Estela Dall', Ruaro Maria Eduarda, Wolfran Luciana, Faria Caique Aparecido, Fukushima Fabiola Bono
Federal University of Paraná, Palotina, PR, Brazil.
Top Companion Anim Med. 2025 Jan-Feb;64:100945. doi: 10.1016/j.tcam.2024.100945. Epub 2024 Dec 18.
Despite the increasing use of drugs to facilitate feline management in veterinary care, there is still a lack of information on the anxiolytic and sedative effects and their specific physiological impacts. We aimed to compare the sedative, hematological, biochemical and cardiovascular effects of oral single-dose trazodone and gabapentin, alone or in combination, in 8 healthy adult mixed-breed domestic cats on a prospective, randomized, cross-over, and placebo-controlled study. Cats were assigned to receive an oral single dose of trazodone (50 mg) (TG), gabapentin (100 mg) (GG), trazodone (50 mg) and gabapentin (100 mg) (GTG), or placebo (PG). Sedation score, physiological, hematological, biochemical, and cardiovascular variables were assessed at baseline and 120 minutes after drug administration. The mean dose of trazodone was 12.1± 1.1 mg/kg and gabapentin 24.2± 2.3 mg/kg. All data were normally distributed. Blood tests remained within the reference range, but plasma protein increased by 3.78 % in TG. Trazodone alone and associated with gabapentin significantly reduced respiratory rate and systolic blood pressure compared to baseline and placebo. GTG showed a reduction in heart rate and the highest sedation scores. Short-duration excitatory reactions were observed in 37.5 % of the cats in GTG and 12.5 % in TG. Isovolumetric relaxation time (IVRT) increased in GTG and differed statistically from GG. On ECG, no clinically relevant changes were observed. The association of trazodone (50 mg/cat) and gabapentin (100 mg/cat) increases sedation scores compared to gabapentin alone, with a mild impact on HR, RR, BP, and IVRT in cats.
尽管在兽医护理中越来越多地使用药物来辅助猫科动物的管理，但关于抗焦虑和镇静作用及其特定生理影响的信息仍然匮乏。我们旨在通过一项前瞻性、随机、交叉和安慰剂对照研究，比较口服单剂量曲唑酮和加巴喷丁单独或联合使用对8只健康成年混种家猫的镇静、血液学、生化和心血管影响。将猫分为接受口服单剂量曲唑酮（50毫克）（TG组）、加巴喷丁（100毫克）（GG组）、曲唑酮（50毫克）和加巴喷丁（100毫克）（GTG组）或安慰剂（PG组）。在基线和给药后120分钟评估镇静评分、生理、血液学、生化和心血管变量。曲唑酮的平均剂量为12.1±1.1毫克/千克，加巴喷丁为24.2±2.3毫克/千克。所有数据均呈正态分布。血液检查结果仍在参考范围内，但TG组血浆蛋白增加了3.78%。与基线和安慰剂相比，单独使用曲唑酮以及与加巴喷丁联合使用均显著降低了呼吸频率和收缩压。GTG组心率降低且镇静评分最高。在GTG组37.5%的猫和TG组12.5%的猫中观察到短期兴奋反应。GTG组等容舒张时间（IVRT）增加，且与GG组有统计学差异。在心电图上，未观察到临床相关变化。与单独使用加巴喷丁相比，曲唑酮（50毫克/猫）和加巴喷丁（100毫克/猫）联合使用可提高镇静评分，对猫的心率、呼吸频率、血压和IVRT有轻微影响。
