Weiter J J, Delori F C, Wing G L, Fitch K A
Am J Ophthalmol. 1985 Feb 15;99(2):185-7. doi: 10.1016/0002-9394(85)90230-2.
We prospectively evaluated 650 consecutive white patients with senile macular degeneration and compared them to a control group of 363 patients. Ocular pigmentation (iris color and fundus pigmentation) was recorded for each patient, as was hair color (as a child and young adult) and age at evaluation. Patients were from the New England states and Florida. Our most significant finding was that 494 patients with senile macular degeneration (76%) had light-colored irides compared with 145 of the controls (40%). Fundus pigmentation closely corresponded to iris pigmentation (P less than 0.01). Hair color was blond or light brown in 370 of the patients with senile macular degeneration (57%) and in 105 of the controls (29%). Further, there was a tendency for individuals with lightly pigmented irides to have senile macular degeneration at an earlier age than those with dark irides (P less than .01). Thus, increased ocular pigmentation tends to decrease the risk of developing senile macular degeneration.
我们前瞻性地评估了650例连续性老年性黄斑变性白人患者，并将其与363例患者的对照组进行比较。记录了每位患者的眼部色素沉着（虹膜颜色和眼底色素沉着），以及发色（儿童和青年时期）和评估时的年龄。患者来自新英格兰各州和佛罗里达州。我们最显著的发现是，494例老年性黄斑变性患者（76%）虹膜颜色较浅，而对照组中有145例（40%）。眼底色素沉着与虹膜色素沉着密切相关（P<0.01）。370例老年性黄斑变性患者（57%）和105例对照组患者（29%）的发色为金色或浅棕色。此外，虹膜色素较浅的个体比虹膜色素较深的个体患老年性黄斑变性的年龄更早（P<0.01）。因此，眼部色素沉着增加往往会降低患老年性黄斑变性的风险。
