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精准肿瘤学:利用癌症基因组学推动靶向治疗进展。

Precision oncology: Using cancer genomics for targeted therapy advancements.

作者信息

Avci Cigir Biray, Bagca Bakiye Goker, Shademan Behrouz, Takanlou Leila Sabour, Takanlou Maryam Sabour, Nourazarian Alireza

机构信息

Department of Medical Biology, Faculty of Medicine, Ege University, Izmir, Turkey.

Department of Medical Biology, Faculty of Medicine, Adnan Menderes University, Aydın, Turkey.

出版信息

Biochim Biophys Acta Rev Cancer. 2025 Feb;1880(1):189250. doi: 10.1016/j.bbcan.2024.189250. Epub 2024 Dec 17.

Abstract

Cancer genomics plays a crucial role in oncology by enhancing our understanding of how genes drive cancer and facilitating the development of improved treatments. This field meticulously examines various cancers' genetic makeup through various methodologies, leading to groundbreaking discoveries. Innovative tools such as rapid gene sequencing, single-cell studies, spatial gene mapping, epigenetic analysis, liquid biopsies, and computational modeling have significantly progressed the field. These techniques uncover genetic alterations, tumor heterogeneity, and the evolutionary dynamics of cancers. Genetic abnormalities and molecular markers that initiate and propagate distinct cancer types are classified according to tumor type. The integration of precision medicine with cancer genomics emphasizes the significance of utilizing genetic data in treatment decision-making, enabling personalized care and enhancing patient outcomes. Critical topics in cancer genomics encompass tumor diversity, alterations in non-coding DNA, epigenetic modifications, cancer-specific proteins, metabolic changes, and the impact of inherited genes on cancer risk.

摘要

癌症基因组学通过加深我们对基因如何驱动癌症的理解以及促进改进治疗方法的开发,在肿瘤学中发挥着至关重要的作用。该领域通过各种方法精心研究各种癌症的基因构成,从而带来了开创性的发现。快速基因测序、单细胞研究、空间基因图谱绘制、表观遗传分析、液体活检和计算建模等创新工具显著推动了该领域的发展。这些技术揭示了基因改变、肿瘤异质性以及癌症的进化动态。引发和传播不同癌症类型的基因异常和分子标志物根据肿瘤类型进行分类。精准医学与癌症基因组学的整合强调了在治疗决策中利用基因数据以实现个性化护理并改善患者治疗效果的重要性。癌症基因组学中的关键主题包括肿瘤多样性、非编码DNA的改变、表观遗传修饰、癌症特异性蛋白质、代谢变化以及遗传基因对癌症风险的影响。

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