Velumani Prabu, Palani Naveen, Antalin Casmie A, Senthilvel Rajeswari, Parthasarthy Vijaya
Nanodrug Co-Delivery Systems Laboratory, Department of Nanoscience and Technology, Bharathiar University, Coimbatore 641046, Tamil Nadu, India.
Nanodrug Co-Delivery Systems Laboratory, Department of Nanoscience and Technology, Bharathiar University, Coimbatore 641046, Tamil Nadu, India.
Toxicol In Vitro. 2025 Apr;104:106000. doi: 10.1016/j.tiv.2024.106000. Epub 2024 Dec 17.
The widespread use of nanoparticles raises substantial environmental, health, and safety issues. The specific mechanisms by which they impact plants and animals, as well as the entire scope of their possible impact, are still unknown. The current work investigates the impact of varying CuO NPs concentrations on phytotoxicity, cytotoxicity, genotoxicity, and antioxidant activity. Exposure of Mung bean seeds to CuO NPs results in the uptake of these particles by the roots and their subsequent transportation to various plant components, including the root, stem, and leaf. This uptake of CuO NPs triggers the production of reactive oxygen species (ROS). The CuO NPs can induce toxicological consequences due to their heightened propensity to produce excessive amounts of ROS. The absorption of CuO NPs might cause deformation and disintegration of the erythrocyte membrane, resulting in cell rupture due to osmotic pressure. The Allium cepa cytotoxicity study aimed to examine the harmful effects of CuO NPs and assess their impact on cellular structures at a microscopic scale. This work aims to analyze the cellular interaction of CuO NPs by measuring the Mitotic Index (MI) in the root cells of Allium cepa. The CuO NPs rapidly interact with plant and human cells, as well as chromosomes, leading to nano-phytotoxicity, nano-cytotoxicity, and nano-genotoxicity.
纳米颗粒的广泛使用引发了重大的环境、健康和安全问题。它们影响植物和动物的具体机制以及可能产生影响的整个范围仍然未知。当前的工作研究了不同浓度的氧化铜纳米颗粒对植物毒性、细胞毒性、遗传毒性和抗氧化活性的影响。将绿豆种子暴露于氧化铜纳米颗粒会导致这些颗粒被根部吸收，并随后运输到植物的各个部位，包括根、茎和叶。这种对氧化铜纳米颗粒的吸收会触发活性氧（ROS）的产生。由于氧化铜纳米颗粒产生过量ROS的倾向增加，它们会引发毒理学后果。氧化铜纳米颗粒的吸收可能会导致红细胞膜的变形和分解，由于渗透压导致细胞破裂。洋葱细胞毒性研究旨在检查氧化铜纳米颗粒的有害影响，并在微观尺度上评估它们对细胞结构的影响。这项工作旨在通过测量洋葱根尖细胞的有丝分裂指数（MI）来分析氧化铜纳米颗粒的细胞相互作用。氧化铜纳米颗粒与植物和人类细胞以及染色体迅速相互作用，导致纳米植物毒性、纳米细胞毒性和纳米遗传毒性。
