Hanratty Brenna, Hauck Anna, Foskett Amanda, Foster J D
Friendship Hospital for Animals, Washington, District of Columbia, USA.
J Vet Intern Med. 2025 Jan-Feb;39(1):e17283. doi: 10.1111/jvim.17283.
A 9-year-old male castrated golden retriever cross was evaluated for an acute onset of ataxia. A complete blood count revealed marked leukocytosis, anemia, and thrombocytopenia. Leukocytosis was characterized by marked lymphocytosis, monocytosis, neutropenia, and eosinopenia. Flow cytometry identified CD34+ leukocytosis with cells that did not express lineage antigens, suggesting the most likely diagnosis of either acute lymphoid or myeloid leukemia. Leukoreduction via leukapheresis was elected to reduce the disease burden before initiating chemotherapy. Postleukoreduction, the dog had a 54% decrease in their white blood cell count. The dog completed multiple weeks of traditional cyclophosphamide, doxorubicin, vincristine, prednisone (CHOP)-based treatment and had a survival time of 43 days before the owner elected humane euthanasia. To our knowledge, this report represents a case of acute leukemia in a dog treated with leukoreduction before starting chemotherapy.
一只9岁去势的金毛寻回犬杂交犬因急性共济失调接受评估。全血细胞计数显示明显的白细胞增多、贫血和血小板减少。白细胞增多的特征是明显的淋巴细胞增多、单核细胞增多、中性粒细胞减少和嗜酸性粒细胞减少。流式细胞术鉴定出CD34 +白细胞增多，细胞不表达谱系抗原，提示最可能的诊断为急性淋巴细胞白血病或髓细胞白血病。在开始化疗前，选择通过白细胞单采术进行白细胞去除以减轻疾病负担。白细胞去除术后，该犬白细胞计数下降了54%。这只狗完成了多周基于传统环磷酰胺、阿霉素、长春新碱、泼尼松（CHOP）的治疗，在主人选择实施安乐死之前存活了43天。据我们所知，本报告代表了一例在开始化疗前接受白细胞去除治疗的犬急性白血病病例。
