Maeda-Minami Ayako, Takashima Misuzu, Morisaki Yukako, Ehara Shunsuke, Kato Seiichi, Saito Kazuhiro, Tanaka Tomokazu, Shikamura Yoshiaki, Mano Yasunari
Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Chiba, Noda, 278-8510, Japan.
Pinokio Pharmacy, Tochigi, Japan.
BMC Oral Health. 2024 Dec 19;24(1):1514. doi: 10.1186/s12903-024-05299-y.
With the rise in the older population, it has become important to understand the relationship between oral frailty and drug use to consider appropriate medical interventions and drug use for older persons.
To clarify the relationship among oral frailty, drug use, and other patient backgrounds and to identify relevant factors using information from patient questionnaires and pharmacy medication history records.
This cross-sectional study involved community-dwelling older adults. Older adults aged ≥ 65 years who visited 44 pharmacies in Tochigi Prefecture, Japan, with their prescriptions between July 1 and September 10, 2021, and who were able to complete the questionnaire independently were eligible for the study. An oral Frailty Index-8 score ≥ 4 was used to define the oral frailty group, while a score of 0-3 was used to define the non-oral frailty group. A multivariate logistic regression analysis was conducted to identify relevant factors for oral frailty, with oral frailty as the dependent variable and items from the questionnaire and drug survey as independent variables.
A total of 1,386 eligible participants were included in this study, and 761 (54.9%) had oral frailty. Multivariate logistic regression analysis showed that frailty, number of natural teeth (fewer than 20), and benzodiazepine use were significantly associated with oral frailty (p < 0.001, p < 0.001, and p = 0.037, respectively).
Our results will provide evidence for community pharmacists to provide appropriate patient education, recommend consultations with dental care providers, and assist in community healthcare coordination.
随着老年人口的增加，了解口腔脆弱与药物使用之间的关系对于考虑为老年人采取适当的医疗干预措施和药物使用变得至关重要。
通过患者问卷和药房用药史记录中的信息，阐明口腔脆弱、药物使用和其他患者背景之间的关系，并确定相关因素。
这项横断面研究纳入了社区居住的老年人。2021年7月1日至9月10日期间，年龄≥65岁、前往日本枥木县44家药房并持有处方且能够独立完成问卷的老年人符合研究条件。口腔脆弱指数-8评分≥4被用来定义口腔脆弱组，而0-3分则被用来定义非口腔脆弱组。以口腔脆弱为因变量，问卷项目和药物调查项目为自变量，进行多因素逻辑回归分析以确定口腔脆弱的相关因素。
本研究共纳入1386名符合条件的参与者，其中761名（54.9%）有口腔脆弱。多因素逻辑回归分析显示，身体虚弱、天然牙数量（少于20颗）和苯二氮䓬类药物的使用与口腔脆弱显著相关（分别为p<0.001、p<0.001和p=0.037）。
我们的研究结果将为社区药剂师提供证据，以便他们提供适当的患者教育、建议与牙科护理提供者进行咨询，并协助社区医疗协调。
