Nakagoshi Natsuki, Locatelli Fabricio M, Kitamura Sonoe, Hirota Seiji, Kawano Takashi
Department of Anesthesiology and Intensive Care Medicine, Kochi Medical School, Oko-cho, Kohasu, Nankoku, 783-8505, Kochi, Japan.
BMC Res Notes. 2024 Dec 19;17(1):369. doi: 10.1186/s13104-024-07023-z.
This study examines the impact of preoperative stress on postoperative neuroinflammation and associated cognitive dysfunction, with a focus on aged individuals. The goal is to determine whether managing preoperative stress can enhance postoperative outcomes and lower the risk of cognitive impairment.
In aged rats, preoperative restraint stress significantly worsened neuroinflammation and cognitive deficits following abdominal surgery. Elevated levels of pro-inflammatory cytokines were observed in the hippocampus and medial prefrontal cortex two days post-surgery, and these effects persisted for twenty-eight days. In contrast, adult rats did not show significant changes in neuroinflammation or cognitive function due to preoperative restraint stress. An ex vivo analysis indicated that hippocampal microglia from aged rats exhibited an intensified proinflammatory response to lipopolysaccharide stimulation, further heightened by preoperative restraint stress. These findings suggest that managing preoperative stress could mitigate these adverse effects, leading to better postoperative recovery and cognitive health in elderly patients.
本研究探讨术前应激对术后神经炎症及相关认知功能障碍的影响，重点关注老年个体。目标是确定管理术前应激是否能改善术后结局并降低认知障碍风险。
在老年大鼠中，术前束缚应激显著加重了腹部手术后的神经炎症和认知缺陷。术后两天，海马体和内侧前额叶皮质中促炎细胞因子水平升高，且这些影响持续了28天。相比之下，成年大鼠并未因术前束缚应激而在神经炎症或认知功能上表现出显著变化。体外分析表明，老年大鼠的海马小胶质细胞对脂多糖刺激表现出增强的促炎反应，术前束缚应激进一步加剧了这种反应。这些发现表明，管理术前应激可以减轻这些不良影响，从而使老年患者术后恢复更好、认知健康状况更佳。
