Geller B, Cooper T B, Farooki Z Q, Chestnut E C
Am J Psychiatry. 1985 Mar;142(3):336-8. doi: 10.1176/ajp.142.3.336.
Eight adolescents with major depressive disorder were treated with nortriptyline and six adolescents with delusional depression were treated with combined nortriptyline and chlorpromazine. Dose and plasma levels of nortriptyline for the two groups were compared. The delusional group receiving combined drug treatment needed significantly less nortriptyline than did the nondelusional group receiving only nortriptyline to obtain similar mean steady state plasma levels of the drug. The mean plasma chlorpromazine levels were quite low.
八名患有重度抑郁症的青少年接受了去甲替林治疗，六名患有妄想性抑郁症的青少年接受了去甲替林与氯丙嗪联合治疗。比较了两组的去甲替林剂量和血浆水平。接受联合药物治疗的妄想组获得与仅接受去甲替林治疗的非妄想组相似的平均稳态血浆药物水平所需的去甲替林显著更少。氯丙嗪的平均血浆水平相当低。
