Offline Adaptive Radiotherapy for Large Non-small Cell Lung Cancer With Volumetric Modulated Arc Therapy Replanning After Creation of Dose Distribution Using Cone-Beam Computed Tomographic Images of Image-Guided Radiotherapy.

There is a paucity of studies reporting the use of automated contouring function on cone-beam computed tomography (CBCT) images acquired during image-guided radiotherapy (IGRT) with offline adaptive radiotherapy for locally advanced non-small cell lung cancer (NSCLC). This case report discusses the use of an automated contouring function on CBCT images acquired during IGRT to quantify the dose distribution variations associated with tumor shrinkage in a patient with large NSCLC. A 72-year-old woman with locally advanced squamous cell carcinoma of the lung (T4N1M0; tumor diameter: 14 cm) underwent chemoradiotherapy. Two offline adaptive radiotherapy sessions were performed, resulting in no evidence of recurrence or distant metastasis, as well as no side effects of Grade 2 or higher toxicity.