Aryanian Zeinab, Kamyab Kambiz, Shakoei Safoura, Etesami Ifa, Azhari Vahidehsadat, Hesami Sami, Khayyat Azadeh, Hatami Parvaneh
Autoimmune Bullous Diseases Research Center Tehran University of Medical Sciences Tehran Iran.
Department of Dermatology, Razi Hospital Tehran University of Medical Sciences Tehran Iran.
Health Sci Rep. 2024 Dec 18;7(12):e70274. doi: 10.1002/hsr2.70274. eCollection 2024 Dec.
Spitz nevus is a rare benign tumor classified among unusual melanocytic nevi. This study aimed to identify the demographic, clinical, and histopathological characteristics of Spitz nevus among Iranian patients.
This descriptive, retrospective study involved reviewing the records of patients diagnosed with Spitz nevus at a referral and academic hospital in Iran between 2016 and 2021. Data were extracted regarding demographic characteristics, including age, gender, location, clinical symptoms, disease duration, medical history, and medication history. Additionally, biopsied lesions were evaluated for histopathological features.
A total of 86 patients were evaluated, comprising 37 males (43.5%) and 49 females (55.5%). The mean age was 15.6 years (SD ± 14.8). The most common sites of involvement were the upper extremities (23.3%) and face (17.4%). Disease durations of 1 and 2 years were the most prevalent, observed in 24 (27.9%) and 26 patients (30.2%), respectively. Notably, none of the patients had any underlying diseases. Histopathological evaluation revealed compound Spitz nevus in 25 patients (29.4%), junctional Spitz nevus in 14 patients (16.5%), and dermal Spitz nevus in 10 patients (11.8%).
This study provides a comprehensive overview of the demographics, clinical presentation, and histopathological features of Spitz nevus among Iranian patients, highlighting the necessity for ongoing research and innovation in diagnostic techniques.
斯皮茨痣是一种罕见的良性肿瘤，归类于不寻常的黑素细胞痣。本研究旨在确定伊朗患者中斯皮茨痣的人口统计学、临床和组织病理学特征。
本描述性回顾性研究涉及回顾2016年至2021年期间在伊朗一家转诊和学术医院被诊断为斯皮茨痣的患者记录。提取了有关人口统计学特征的数据，包括年龄、性别、部位、临床症状、病程、病史和用药史。此外，对活检病变进行了组织病理学特征评估。
共评估了86例患者，其中男性37例（43.5%），女性49例（55.5%）。平均年龄为15.6岁（标准差±14.8）。最常见的受累部位是上肢（23.3%）和面部（17.4%）。病程为1年和2年的最为普遍，分别在24例（27.9%）和26例患者（30.2%）中观察到。值得注意的是，所有患者均无任何基础疾病。组织病理学评估显示，25例患者（29.4%）为复合性斯皮茨痣，14例患者（16.5%）为交界性斯皮茨痣，10例患者（11.8%）为真皮性斯皮茨痣。
本研究全面概述了伊朗患者中斯皮茨痣的人口统计学、临床表现和组织病理学特征，强调了在诊断技术方面持续研究和创新的必要性。
