Srivastava Amrita, Mahilkar Shakuntala, Upadhyaya Chandrama Prakash, Mishra Prashant Kumar, Malinda Raj Rajeshwar, Sonkar Subash Chandra, Koner Bidhan Chandra
Department of Biotechnology, Dr. Harisingh Gour Vishwavidyalaya (A Central University), Madhya Pradesh, India.
Vector-Borne Diseases Group, International Centre for Genetic Engineering and Biotechnology (ICGEB), New Delhi, India.
Yale J Biol Med. 2024 Dec 19;97(4):505-514. doi: 10.59249/QSPC8835. eCollection 2024 Dec.
Alkhumra fever is a viral disease caused by the Alkhumra hemorrhagic fever virus (AHFV). It belongs to family , genus . AHFV is primarily transmitted to humans through the bite of infected ticks, for example, . This disease was first identified in the Kingdom of Saudi Arabia (KSA) in 1995 and then reported in other countries of the Arabian Peninsula and the Middle East. The AHFV genome consists of a positive-sense, single-stranded RNA molecule of approximately 10.2 kilobases (kb) in length. The Open Reading Frame (ORF) encodes a polyprotein precursor that is processed by viral and host proteases to yield individual viral proteins. The polyprotein precursor is cleaved by viral proteases and host signal peptidases into three structural and seven non-structural proteins. AHFV can cause a range of clinical manifestations, from mild flu-like symptoms to severe hemorrhagic fever. In this review, we focus on insightful understanding of molecular biology, pathogenesis, and their potential therapeutic targets for AHFV.
阿勒胡姆拉热是一种由阿勒胡姆拉出血热病毒（AHFV）引起的病毒性疾病。它属于 科， 属。AHFV主要通过受感染蜱虫的叮咬传播给人类，例如 。这种疾病于1995年在沙特阿拉伯王国首次被发现，随后在阿拉伯半岛和中东的其他国家也有报道。AHFV基因组由一个长度约为10.2千碱基（kb）的正链单链RNA分子组成。开放阅读框（ORF）编码一个多蛋白前体，该前体由病毒和宿主蛋白酶加工产生单个病毒蛋白。多蛋白前体被病毒蛋白酶和宿主信号肽酶切割成三种结构蛋白和七种非结构蛋白。AHFV可引起一系列临床表现，从轻度流感样症状到严重出血热。在本综述中，我们重点深入了解AHFV的分子生物学、发病机制及其潜在治疗靶点。
