Li Sumei, Wu Xingye, Yu Jingming, Jiang Jiaqin, Qi Ruibing, Chen Bing, Li Zhengming
Department of Endocrinology and Metabolism, Guangxi Hospital Division of The First Affiliated Hospital, Sun Yat-sen University, Nanning, 530022, People's Republic of China.
Department of Endocrinology and Metabolism, Guangxi Academy of Medical Sciences and the People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, 530021, People's Republic of China.
Diabetes Metab Syndr Obes. 2024 Dec 15;17:4777-4787. doi: 10.2147/DMSO.S490347. eCollection 2024.
The aim of the present study was to investigate how thyroid hormone levels are related to controlled attenuation parameters (CAP), which may provide insights for understanding the role of these factors in hepatic steatosis.
A total of 3461 participants who underwent CAP diagnosis between 2018 and 2023 were included. The associations between thyroid hormone levels and CAP were evaluated through multiple linear regression, restricted cubic splines (RCS) and threshold effect analyses.
Multiple linear regression analysis revealed an inverse relationship between free thyroxine (FT4) and CAP, with a coefficient of -0.855 and a confidence interval of -1.297 to -0.412. The negative connection in a subset examination persisted in males [-0.729 (-1.295, -0.162)] and females [-1.234 (-1.996, -0.473)]. A strong correlation was found between free 3,5,3'-triiodothyronine (FT3) and CAP, with values of 2.182 (1.154, 3.211). Further analysis was conducted on both male [1.626 (0.188, 3.065)] and female [2.835 (1.137, 4.533)] subgroups. In the severe liver steatosis group, there was a significant negative correlation between FT3 and CAP based on the subgroup analysis stratified by the level of liver steatosis [-3.804 (-6.711, -0.898)]. The RCS analysis showed a nonlinear association between FT4 and CAP, with a turning point at 11.14 pmol/L.
There was a significant linear and nonlinear relationship between FT4, FT3 and CAP. Thyroid hormones could have a significant impact on liver steatosis, offering fresh perspectives on how to prevent and treat this condition.
本研究旨在探讨甲状腺激素水平与受控衰减参数（CAP）之间的关系，这可能为理解这些因素在肝脂肪变性中的作用提供见解。
纳入了2018年至2023年间接受CAP诊断的3461名参与者。通过多元线性回归、受限立方样条（RCS）和阈值效应分析评估甲状腺激素水平与CAP之间的关联。
多元线性回归分析显示游离甲状腺素（FT4）与CAP呈负相关，系数为-0.855，置信区间为-1.297至-0.412。在亚组分析中，男性[-0.729（-1.295，-0.162）]和女性[-1.234（-1.996，-0.473）]中这种负相关关系持续存在。游离三碘甲状腺原氨酸（FT3）与CAP之间存在强相关性，值为2.182（1.154，3.211）。对男性[1.626（0.188，3.065）]和女性[2.835（1.137，4.533）]亚组均进行了进一步分析。在重度肝脂肪变性组中，根据肝脂肪变性水平分层的亚组分析显示FT3与CAP之间存在显著负相关[-3.804（-6.711，-0.898）]。RCS分析显示FT4与CAP之间存在非线性关联，转折点为晚上11.14 pmol/L。
FT4、FT3与CAP之间存在显著的线性和非线性关系。甲状腺激素可能对肝脂肪变性有显著影响，为预防和治疗这种疾病提供了新的视角。
