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多发性硬化前驱期的病假情况及其与诊断延迟的关联:一篇简短报告。

Sick leave in the prodromal phase of multiple sclerosis and its association with diagnostic delay: A short report.

作者信息

Machado Alejandra, Pettersson Emma, Alexanderson Kristina, Hillert Jan, Friberg Emilie

机构信息

Division of Insurance Medicine, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.

Division of Neurology, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.

出版信息

Mult Scler J Exp Transl Clin. 2024 Dec 18;10(4):20552173241305982. doi: 10.1177/20552173241305982. eCollection 2024 Oct-Dec.

Abstract

The prodromal features of multiple sclerosis (MS) are non-specific and are prevalent in the general population. Several studies indicate an increased use of healthcare resources by individuals with MS in the years preceding their diagnosis, suggesting a trend of deteriorating health prior to the clinical manifestation of MS. This study aimed to capture the possible associations of sick leave with the timing of the diagnosis of MS. Our findings suggest that sick leave with neurological diagnoses - excluding MS, and other diagnoses during the year before MS onset is associated with a shorter time to MS diagnosis.

摘要

多发性硬化症(MS)的前驱特征不具有特异性,在普通人群中很常见。多项研究表明,MS患者在确诊前几年对医疗资源的使用有所增加,这表明在MS临床表现之前健康状况有恶化的趋势。本研究旨在找出病假与MS诊断时间之间可能存在的关联。我们的研究结果表明,患有神经疾病诊断(不包括MS)以及在MS发病前一年的其他诊断的病假与MS诊断时间较短有关。

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Misdiagnosis of Multiple Sclerosis: Past, Present, and Future.多发性硬化症的误诊:过去、现在和未来。
Curr Neurol Neurosci Rep. 2024 Nov;24(11):547-557. doi: 10.1007/s11910-024-01371-w. Epub 2024 Sep 7.
3
The multiple sclerosis prodrome.多发性硬化前驱期。
Nat Rev Neurol. 2021 Aug;17(8):515-521. doi: 10.1038/s41582-021-00519-3. Epub 2021 Jun 21.
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Prodromal symptoms of multiple sclerosis in primary care.多发性硬化症的初级保健前驱症状。
Ann Neurol. 2018 Jun;83(6):1162-1173. doi: 10.1002/ana.25247. Epub 2018 May 30.

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